Febuxostat

Name: Febuxostat Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

17 interactions 57 cited references

Also sold as: Uloric Uloric®

About Febuxostat

Febuxostat is used to treat gout in adults who were not treated successfully with or who are not able to take allopurinol (Aloprim, Zyloprim). Gout is a type of arthritis in which uric acid, a naturally occurring substance in the body, builds up in the joints and causes sudden attacks of redness, swelling, pain, and he… Read the full Febuxostat drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Azathioprine Mercaptopurine Theophylline Talazoparib Tenofovir Alafenamide Methotrexate Injection

2 Contraindicated 15 Major

All (17) Contraindicated (2) Major (15)

Contraindicated

Febuxostat Azathioprine Azasan Increased azaTHIOprine exposure and an increased risk of hepatotoxicity Details Febuxostat Mercaptopurine Purinethol® Increased azaTHIOprine exposure and an increased risk of hepatotoxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.