Febuxostat
17 interactions 57 cited referencesFebuxostat is used to treat gout in adults who were not treated successfully with or who are not able to take allopurinol (Aloprim, Zyloprim). Gout is a type of arthritis in which uric acid, a naturally occurring substance in the body, builds up in the joints and causes sudden attacks of redness, swelling, pain, and he… Read the full Febuxostat drug information page →
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Major
Febuxostat Alpelisib Piqray Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Febuxostat Clomipramine Anafranil Increased clomiPRAMINE exposure Details Febuxostat Dextroamphetamine Dexedrine Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Febuxostat Haloperidol Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Febuxostat Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Febuxostat Lisdexamfetamine Arynta Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Febuxostat Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Febuxostat Rosuvastatin Crestor Increased rosuvastatin exposure and an increased risk of myopathy and rhabdomyolysis Details Febuxostat Talazoparib Talzenna Increased talazoparib exposure and an increased risk of talazoparib-related adverse reactions Details Febuxostat Tenofovir Alafenamide Increased tenofovir alafenamide exposure Details Febuxostat Theophylline Accurbron® Increased exposure to 1-methylxanthine, one of the major metabolites of theophylline Details Febuxostat Topotecan Hycamtin Increased topotecan exposure and risk of adverse events Details Febuxostat Tramadol ConZip Increased traMADol exposure and reduced exposure of the active metabolite Details Febuxostat Ubrogepant Ubrelvy Increased ubrogepant exposure Details Febuxostat Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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