Fentanyl Transdermal Patch and Metreleptin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Fentanyl Transdermal Patch
Metreleptin
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Altered exposure to fentanyl
Interaction Deep Dive
Leptin is a cytokine that may alter CYP450 enzyme formation. Use caution with coadministration of CYP450-metabolized drugs with a narrow therapeutic index (eg, fentanyl) with metreleptin, as clinically relevant effects may result. Monitor fentanyl therapeutic effects following metreleptin initiation or discontinuation and adjust the fentanyl dose as needed1.
Why it happens (mechanism)
Potential alteration in CYP450 enzyme formation by metreleptin
Common questions
Can I take Fentanyl Transdermal Patch and Metreleptin together?
Altered exposure to fentanyl Always confirm with your pharmacist or prescriber before making any change.
How serious is the Fentanyl Transdermal Patch and Metreleptin interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Fentanyl Transdermal Patch or Metreleptin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: MYALEPT(TM) lyophilized powder for subcutaneous injection, metreleptin lyophilized powder for subcutaneous injection. Bristol-Myers Squibb (per FDA), Princeton, NJ, 2014.
Keep reading about Fentanyl Transdermal Patch
Keep reading about Metreleptin
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