Fentanyl Transdermal Patch

493 interactions 844 cited references
Also sold as: Duragesic®
About Fentanyl Transdermal Patch

Fentanyl patches are used to relieve severe pain in people who are expected to need pain medication around the clock for a long time and who cannot be treated with other medications. Fentanyl is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system resp… Read the full Fentanyl Transdermal Patch drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Fentanyl Transdermal Patch Abametapir Increased exposure of CYP3A4 substrate Details Fentanyl Transdermal Patch Acepromazine PROMACE Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Fentanyl Transdermal Patch Aclidinium Tudorza Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Fentanyl Transdermal Patch Alefacept Decreased fentanyl plasma concentrations Details Fentanyl Transdermal Patch Alfentanil Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Fentanyl Transdermal Patch Almotriptan Increased risk of serotonin syndrome Details Fentanyl Transdermal Patch Alprazolam Xanax Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Fentanyl Transdermal Patch Amantadine Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Fentanyl Transdermal Patch Amifampridine Increased risk of seizures Details Fentanyl Transdermal Patch Amiloride Reduced diuretic efficacy Details Fentanyl Transdermal Patch Amineptine Increased risk of serotonin syndrome Details Fentanyl Transdermal Patch Amiodarone Nexterone Cardiac toxicity (low cardiac output) and an increased risk of fentanyl toxicity (CNS depression, respiratory depression) Details Fentanyl Transdermal Patch Amitriptyline Elavil Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Fentanyl Transdermal Patch Amitriptylinoxide Increased risk of serotonin syndrome Details Fentanyl Transdermal Patch Amobarbital Amytal Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Fentanyl Transdermal Patch Amoxapine Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Fentanyl Transdermal Patch Amphetamine Dexedrine An increased risk of serotonin syndrome Details Fentanyl Transdermal Patch Amprenavir Increased fentaNYL exposure and an increased risk of prolonged opioid effects Details Fentanyl Transdermal Patch Anileridine Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Fentanyl Transdermal Patch Apalutamide Erleada Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Fentanyl Transdermal Patch Aprepitant Aponvie Increased fentaNYL exposure and an increased risk of prolonged opioid effects Details Fentanyl Transdermal Patch Aripiprazole Abilify Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Fentanyl Transdermal Patch Aripiprazole Lauroxil Aristada Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Fentanyl Transdermal Patch Armodafinil Nuvigil Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Fentanyl Transdermal Patch Asciminib Scemblix Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Fentanyl Transdermal Patch Asenapine Saphris Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Fentanyl Transdermal Patch Atazanavir Reyataz Increased fentaNYL exposure and an increased risk of prolonged opioid effects Details Fentanyl Transdermal Patch Atropine Atropen Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Fentanyl Transdermal Patch Avacopan Tavneos Increased exposure to CYP3A4 substrate Details Fentanyl Transdermal Patch Baclofen Fleqsuvy Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Fentanyl Transdermal Patch Belladonna Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.