Drug Interaction Report

Feprazone and Epoprostenol: Interaction Details

A pharmacist-reviewed analysis of the Feprazone and Epoprostenol interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Epoprostenol

Flolan Flolan® Veletri Veletri®
+

Feprazone

No brand names on record
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 91 documented Feprazone interactions, 59 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

An increased risk of bleeding

Interaction Deep Dive

Coadministration of antiplatelet agents and NSAIDs can increase the risk of bleeding12, including gastrointestinal bleeding 3, especially with chronic use of the NSAID 4. Use caution and monitor the patient for signs of bleeding with concomitant use of antiplatelet agents and NSAIDs 562.

Why it happens (mechanism)

Additive effects on hemostasis

Common questions

Can I take Feprazone and Epoprostenol together?

An increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.

How serious is the Feprazone and Epoprostenol interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Feprazone or Epoprostenol need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (6)

  1. Product Information: ANAPROX(R) DS oral tablets, naproxen sodium oral tablets. Canton Laboratories, LLC (per FDA), Alpharetta, GA, 2016. DailyMed
  2. Product Information: COMBOGESIC(R) oral tablets, acetaminophen ibuprofen oral tablets. AFT Pharmaceuticals Inc (per FDA), Highland, MD, 2023. DailyMed
  3. Product Information: PLAVIX(R) oral tablets, clopidogrel bisulfate oral tablets. sanofi-aventis US LLC (per FDA), Bridgewater, NJ, 2022. DailyMed
  4. Product Information: EFFIENT(R) oral tablets, prasugrel oral tablets. Daiichi Sankyo, Inc. and Lilly USA, LLC (per FDA), Indianapolis, IN, 2015. DailyMed
  5. Product Information: ZORVOLEX(R) oral capsules, diclofenac oral capsules. Iroko Pharmaceuticals, LLC (per FDA), Philadelphia, PA, 2016. DailyMed
  6. Product Information: CALDOLOR(R) intravenous injection, ibuprofen intravenous injection. Cumberland Pharmaceuticals Inc. (per FDA), Nashville, TN, 2016. DailyMed
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Epoprostenol

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Feprazone

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Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Epoprostenol + Activated Charcoal American Hellebore American Mistletoe Tyramine Adrafinil Agmatine Algal Oil Andrographis + 128 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.