Epoprostenol

152 interactions 308 cited references
Also sold as: Flolan Flolan® Veletri Veletri®
About Epoprostenol

Epoprostenol injection is used to treat certain kinds of pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Epoprostenol may improve the ability to exercise and slow the worsening of symptoms in patients with PAH.… Read the full Epoprostenol drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abrocitinib Sertraline Heparin Ibuprofen Ketoprofen Methotrexate Injection
1 Contraindicated 115 Major 34 Moderate 2 Minor
All (152) Contraindicated (1) Major (115) Moderate (34) Minor (2)

Contraindicated

Epoprostenol Abrocitinib Cibinqo Increased risk of bleeding Details

Major

Epoprostenol Sertraline An increased risk of bleeding Details Epoprostenol Apixaban Eliquis Increased risk of bleeding and can cause serious, potentially fatal bleeding Details Epoprostenol Azathioprine Azasan An increased risk of hepatotoxicity Details Epoprostenol Betrixaban Bevyxxa® Increased risk of bleeding Details Epoprostenol Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Epoprostenol Clopidogrel Plavix An increased risk of bleeding Details Epoprostenol Dabigatran Pradaxa® Increased risk of bleeding Details Epoprostenol Dabigatran Etexilate Increased risk of bleeding Details Epoprostenol Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Epoprostenol Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Epoprostenol Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Epoprostenol Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Epoprostenol Digoxin Cardoxin® Increased digoxin exposure and an increased risk of digoxin toxicity Details Epoprostenol Edoxaban Savaysa Increased risk of bleeding Details Epoprostenol Aceclofenac An increased risk of bleeding Details Epoprostenol Acemetacin An increased risk of bleeding Details Epoprostenol Acenocoumarol Increased risk of bleeding Details Epoprostenol Amtolmetin Guacil An increased risk of bleeding Details Epoprostenol Argatroban Increased risk of bleeding Details Epoprostenol Bivalirudin Angiomax Increased risk of bleeding Details Epoprostenol Bromfenac Bromsite An increased risk of bleeding Details Epoprostenol Bufexamac An increased risk of bleeding Details Epoprostenol Celecoxib Celebrex An increased risk of bleeding Details Epoprostenol Choline Salicylate An increased risk of bleeding Details Epoprostenol Citalopram Celexa An increased risk of bleeding Details Epoprostenol Clonixin An increased risk of bleeding Details Epoprostenol Danaparoid Increased risk of bleeding Details Epoprostenol Desirudin Iprivask Increased risk of bleeding Details Epoprostenol Desvenlafaxine Pristiq An increased risk of bleeding Details Epoprostenol Dexibuprofen An increased risk of bleeding Details Epoprostenol Dexketoprofen An increased risk of bleeding Details Epoprostenol Diclofenac Aleve Arthritis Pain An increased risk of bleeding Details Epoprostenol Diflunisal Dolobid An increased risk of bleeding Details Epoprostenol Dipyrone An increased risk of bleeding Details Epoprostenol Droxicam An increased risk of bleeding Details Epoprostenol Duloxetine An increased risk of bleeding Details Epoprostenol Escitalopram Lexapro An increased risk of bleeding Details Epoprostenol Etodolac Lodine An increased risk of bleeding Details Epoprostenol Etofenamate An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.