Drug & supplement interaction

Java Tea + Epoprostenol

Epoprostenol brand name: Flolan.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Java Tea has a moderate interaction with Epoprostenol. Some preliminary clinical evidence suggests that Java tea has antihypertensive effects.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Java Tea and Epoprostenol

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIHYPERTENSIVE DRUGS

Why this applies to Epoprostenol

Epoprostenol falls under ANTIHYPERTENSIVE DRUGS — the group Java Tea interacts with.

Some preliminary clinical evidence suggests that Java tea has antihypertensive effects. Further, animal research suggests that Java tea has diuretic properties. Theoretically, taking Java tea with other antihypertensive drugs might increase the effects and risk for hypotension with these drugs.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version. Epoprostenol (Flolan) is a powerful medicine given through a continuous IV pump to widen blood vessels and lower pressure in the lungs for people with pulmonary hypertension. One of its built-in effects is lowering blood pressure throughout the body. Java Tea, on the other hand, may gently nudge blood pressure down too and acts as a mild diuretic, meaning it makes you pass more fluid.

Stack those two together and, in theory, you could lean toward low blood pressure, with symptoms like dizziness, lightheadedness, a faster heartbeat, or feeling faint when you stand. I'll be honest: this is based on how these things work, not solid human studies. Still, because Epoprostenol is such a strong, finely-dosed drug, please loop in your care team before adding Java Tea.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Cicero AF, De Sando V, Izzo R, Vasta A, Trimarco A, Borghi C. Effect of a combined nutraceutical containing Orthosiphon stamineus effect on blood pressure and metabolic syndrome components in hypertensive dyslipidaemic patients: a randomized clinical tria

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Java Tea Also Interacts With Other Medications

Java Tea has 172 moderate known drug interactions in our database — the Epoprostenol one above is one of them. If you take anything else, check it against the full list below.

Moderate 172 No known interaction 2,658 (incl. Epoprostenol)
Taking anything else?

Check Another of Your Medications Against Java Tea

Covers the 2,830 medications we’ve checked against Java Tea. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Epoprostenol

This page covers Java Tea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Epoprostenol page lists 136 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Tyramine (major) and Adrafinil (moderate).

By severity: 4 major · 111 moderate · 21 minor.

From our pharmacist’s overview on the Epoprostenol page

“American hellebore tops my concerns for anyone on epoprostenol (Flolan), the continuous infusion that opens blood vessels in the lungs to treat pulmonary arterial hypertension. The herb lowers blood pressure even in small doses, and stacked on a medicine that already relaxes those vessels, the drop can be dangerous.”

Reviewed by 2 · Jul 18, 2026

Open the Epoprostenol interaction page

One more smart check

Taking Java Tea as Part of a Dietary Supplement Product? Check It for Interactions

We hold 64 real supplement products containing Java Tea, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Java Tea. Your product may carry other ingredients that interact with Epoprostenol too, on top of Java Tea — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Java Tea and Epoprostenol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Java Tea
Steady interest

#1,171 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Epoprostenol
Steady interest

#2,565 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Java Tea

What is Java Tea?

  • Urinary tract health
  • Mild fluid retention
  • Kidney and bladder support
  • Mild diuretic ('water pill') effect
  • Digestive complaints

Java Tea is a Southeast Asian herb traditionally used as a gentle diuretic and for urinary tract and kidney support. Some early lab, animal, and small human studies are encouraging, but high-quality evidence in people is limited, so it should not replace proven treatments. Talk to a pharmacist or doctor before using it, especially if you have kidney problems or take other medicines.

Read the full Java Tea monograph & all interactions
Medication

About Epoprostenol

What Is Epoprostenol Used For?

Brand name: Flolan

Epoprostenol treats pulmonary arterial hypertension (PAH) (WHO Group 1), which is high blood pressure in the arteries of the lungs. It is used to improve exercise capacity.

Both Veletri and Epoprostenol for injection are approved for this use. Studies included mostly people with NYHA Functional Class III–IV symptoms (moderate to severe limits on activity). The causes were mainly idiopathic or heritable PAH, or PAH linked to connective tissue diseases.

See full Epoprostenol drug information
Keep checking

Other Drugs & Java Tea

Browse every other medication we’ve checked against Java Tea — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
0Minor
2,657No known interaction
172 Moderate 2,657 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the Java Tea page.

No interaction 2,657 drugs checked — show the list

We also checked Java Tea against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full Java Tea list.

See the full Java Tea interactions page
See every supplement checked against Epoprostenol, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Java Tea monograph › Uses, safety, and every drug interaction in one place Epoprostenol supplement interactions › Every supplement checked against Epoprostenol, ranked by severity Epoprostenol drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Java Tea and Epoprostenol Together: Common Questions

Can you take Java Tea with Epoprostenol?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Java Tea and Epoprostenol interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Epoprostenol and Java Tea?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.