Finerenone and Thioridazine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Thioridazine
No brand names on recordFinerenone
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced finerenone exposure and reduced efficacy of finerenone
Interaction Deep Dive
Avoid concomitant use of finerenone and a strong or moderate CYP3A4 inducer as it may reduce finerenone exposure, which may reduce finerenone efficacy. Concomitant use of finerenone with rifampicin, a strong CYP3A4 inducer, was predicted to decrease finerenone AUC by 90%. Concomitant use with efavirenz, a moderate CYP3A4 inducer, was predicted to decrease finerenone AUC by 80%1.
Why it happens (mechanism)
Induction of CYP3A4-mediated metabolism of finerenone
Literature reports
1 report — tap to read
a) In drug interaction studies, concomitant use of finerenone with rifampicin, a strong CYP3A4 inducer, was predicted to decrease finerenone AUC by 90%. Concomitant use with efavirenz, a moderate CYP3A4 inducer, was predicted to decrease finerenone AUC by 80% 1.
Common questions
Can I take Finerenone and Thioridazine together?
Reduced finerenone exposure and reduced efficacy of finerenone Always confirm with your pharmacist or prescriber before making any change.
How serious is the Finerenone and Thioridazine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Finerenone or Thioridazine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: KERENDIA(R) oral tablets, finerenone oral tablets. Bayer HealthCare Pharmaceuticals Inc (per FDA), Whippany, NJ, 2025. DailyMed
Keep reading about Thioridazine
Keep reading about Finerenone
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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