Fludrocortisone Acetate

86 interactions 178 cited references
Also sold as: Florinef®
About Fludrocortisone Acetate

Fludrocortisone, a corticosteroid, is used to help control the amount of sodium and fluids in your body. It is used to treat Addison's disease and syndromes where excessive amounts of sodium are lost in the urine. It works by decreasing the amount of sodium that is lost (excreted) in your urine. This medication is some… Read the full Fludrocortisone Acetate drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mifepristone Desmopressin Upadacitinib Tosufloxacin Sparfloxacin Sargramostim
2 Contraindicated 33 Major 48 Moderate 3 Minor
All (86) Contraindicated (2) Major (33) Moderate (48) Minor (3)

Contraindicated

Fludrocortisone Acetate Desmopressin DDAVP Increased risk of severe hyponatremia Details Fludrocortisone Acetate Mifepristone Korlym An increased risk of autoimmune disorders and an increased risk of acute adrenal insufficiency, that may lead to exacerbation or d... Details

Major

Fludrocortisone Acetate Aspirin Acuprin® An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Fludrocortisone Acetate Balofloxacin An increased risk of tendon rupture Details Fludrocortisone Acetate Besifloxacin An increased risk of tendon rupture Details Fludrocortisone Acetate Bupropion Aplenzin Lowering of the seizure threshold Details Fludrocortisone Acetate Carbamazepine Carbatrol Reduced corticosteroids exposure and reduced efficacy of corticosteroids Details Fludrocortisone Acetate Ciprofloxacin An increased risk of tendon rupture Details Fludrocortisone Acetate Enoxacin An increased risk of tendon rupture Details Fludrocortisone Acetate Ethinyl Estradiol Increased corticosteroid exposure Details Fludrocortisone Acetate Fleroxacin An increased risk of tendon rupture Details Fludrocortisone Acetate Flumequine An increased risk of tendon rupture Details Fludrocortisone Acetate Fosphenytoin Cerebyx Reduced corticosteroid exposure Details Fludrocortisone Acetate Gatifloxacin Zymaxid An increased risk of tendon rupture Details Fludrocortisone Acetate Gemifloxacin Factive An increased risk of tendon rupture Details Fludrocortisone Acetate Insulin Aspart, Recombinant Fiasp Reduced blood glucose lowering effect of insulin Details Fludrocortisone Acetate Insulin Glargine, Recombinant Basaglar Reduced blood glucose lowering effect of insulin Details Fludrocortisone Acetate Insulin Icodec-Abae Awiqli Reduced efficacy of insulin icodec-abae Details Fludrocortisone Acetate Levofloxacin Levaquin An increased risk of tendon rupture Details Fludrocortisone Acetate Lomefloxacin An increased risk of tendon rupture Details Fludrocortisone Acetate Macimorelin False-positive or false-negative adult growth hormone deficiency diagnosis Details Fludrocortisone Acetate Methadone Diskets An increased risk of electrolyte disturbances (hypokalemia, hypomagnesemia) Details Fludrocortisone Acetate Moxifloxacin Avelox An increased risk of tendon rupture Details Fludrocortisone Acetate Nadifloxacin An increased risk of tendon rupture Details Fludrocortisone Acetate Norfloxacin An increased risk of tendon rupture Details Fludrocortisone Acetate Ofloxacin Floxin® An increased risk of tendon rupture Details Fludrocortisone Acetate Pazufloxacin An increased risk of tendon rupture Details Fludrocortisone Acetate Pefloxacin An increased risk of tendon rupture Details Fludrocortisone Acetate Phenytoin Dilantin Reduced corticosteroid exposure Details Fludrocortisone Acetate Prulifloxacin An increased risk of tendon rupture Details Fludrocortisone Acetate Rufloxacin An increased risk of tendon rupture Details Fludrocortisone Acetate Sargramostim Leukine Increased myeloproliferative effects of sargramostim Details Fludrocortisone Acetate Sparfloxacin An increased risk of tendon rupture Details Fludrocortisone Acetate Tosufloxacin An increased risk of tendon rupture Details Fludrocortisone Acetate Upadacitinib Rinvoq Increased risk of gastrointestinal perforations Details

Moderate

Fludrocortisone Acetate Acenocoumarol Increased risk of bleeding or diminished effects of acenocoumarol Details Fludrocortisone Acetate Adenovirus Vaccine Type 4, Live An inadequate immunological response to the vaccine Details Fludrocortisone Acetate Adenovirus Vaccine Type 7, Live An inadequate immunological response to the vaccine Details Fludrocortisone Acetate Bacillus Of Calmette And Guerin Vaccine, Live An inadequate immunological response to the vaccine Details Fludrocortisone Acetate Cholera Vaccine, Live An inadequate immunological response to the vaccine Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.