Flunitrazepam

14 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Buprenorphine Aripiprazole Injection Diazepam Nasal Spray Diazepam Rectal Fentanyl Transdermal Patch
13 Major 1 Moderate
All (14) Major (13) Moderate (1)

Major

Flunitrazepam Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Flunitrazepam Buprenorphine Belbuca Explained An increased risk of CNS depression and respiratory depression Details Flunitrazepam Aripiprazole Injection Abilify An increased risk of sedation and orthostatic hypotension Details Flunitrazepam Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Flunitrazepam Diazepam Rectal Diastat Increased risk of CNS depression Details Flunitrazepam Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Flunitrazepam Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Flunitrazepam Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Flunitrazepam Lacosamide Injection Motpoly An increased risk of CNS depression Details Flunitrazepam Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Flunitrazepam Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Flunitrazepam Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Flunitrazepam Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.