Fluorouracil Injection

77 interactions 816 cited references

Also sold as: Adrucil Adrucil® Injection Carac Efudex Favlyxa Fluoroplex Tolak

About Fluorouracil Injection

Fluorouracil is generally used in combination with other medications to treat colon cancer or rectal cancer (cancer that begins in the large intestine) that has gotten worse or spread to other parts of the body. Fluorouracil is used in combination with other medications to treat certain types of breast cancer after sur… Read the full Fluorouracil Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Rubella Virus Vaccine, Live Mumps Virus Vaccine, Live Measles Virus Vaccine, Live Dengue Tetravalent Vaccine, Live Brivudine Bacillus Of Calmette And Guerin Vaccine, Live

11 Contraindicated 61 Major 4 Moderate 1 Minor

All (77) Contraindicated (11) Major (61) Moderate (4) Minor (1)

Contraindicated

Fluorouracil Injection Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Injection Brivudine Increased exposure of 5-fluorouracil Details Fluorouracil Injection Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Injection Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Injection Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Injection Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Injection Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Fluorouracil Injection Tegafur Increased antineoplastic toxicity Details Fluorouracil Injection Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Fluorouracil Injection Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Injection Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Fluorouracil Injection Abrocitinib Cibinqo Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Injection Acenocoumarol Increased vitamin K antagonist exposure and an increased risk of bleeding Details Fluorouracil Injection Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Fluorouracil Injection Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Fluorouracil Injection Aficamten Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Injection Allopurinol Aloprim Reduced capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure and... Details Fluorouracil Injection Avatrombopag Doptelet Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Injection Azanidazole Increased exposure of 5-fluorouracil Details Fluorouracil Injection Benznidazole Increased exposure of 5-fluorouracil Details Fluorouracil Injection Carvedilol Coreg Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Injection Celecoxib Celebrex Increased celecoxib exposure and an increased risk of celecoxib-related adverse effects Details Fluorouracil Injection Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Fluorouracil Injection Cimetidine Tagamet An increased risk of fluorouracil toxicity Details Fluorouracil Injection Deuruxolitinib Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Injection Diclofenac Aleve Arthritis Pain Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Injection Dronabinol Marinol Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Injection Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Injection Erdafitinib Balversa Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Injection Etrasimod Velsipity Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Injection Etravirine Intelence Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Injection Flurbiprofen Ansaid Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Injection Fluvastatin Lescol Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Injection Folic Acid Folacin Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Fluorouracil Injection Fosphenytoin Cerebyx Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and associated phenytoin or fosphenytoin toxicity Details Fluorouracil Injection Glimepiride Amaryl Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Injection Glipizide Glucotrol Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Injection Glyburide DiaBeta® Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Injection Ibuprofen Addaprin Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Injection Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.