Fluorouracil Topical

77 interactions 816 cited references

Also sold as: Carac Carac® Cream Efudex Efudex® Cream Efudex® Solution Fluoroplex Fluoroplex® Cream Tolak

About Fluorouracil Topical

Fluorouracil cream and topical solution are used to treat actinic or solar keratoses (scaly or crusted lesions [skin areas] caused by years of too much exposure to sunlight). Fluorouracil cream and topical solution are also used to treat a type of skin cancer called superficial basal cell carcinoma if usual types of tr… Read the full Fluorouracil Topical drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Rubella Virus Vaccine, Live Mumps Virus Vaccine, Live Measles Virus Vaccine, Live Dengue Tetravalent Vaccine, Live Brivudine Bacillus Of Calmette And Guerin Vaccine, Live

11 Contraindicated 61 Major 4 Moderate 1 Minor

All (77) Contraindicated (11) Major (61) Moderate (4) Minor (1)

Contraindicated

Fluorouracil Topical Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Topical Brivudine Increased exposure of 5-fluorouracil Details Fluorouracil Topical Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Topical Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Topical Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Topical Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Topical Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Fluorouracil Topical Tegafur Increased antineoplastic toxicity Details Fluorouracil Topical Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Fluorouracil Topical Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Topical Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Fluorouracil Topical Abrocitinib Cibinqo Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Topical Acenocoumarol Increased vitamin K antagonist exposure and an increased risk of bleeding Details Fluorouracil Topical Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Fluorouracil Topical Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Fluorouracil Topical Aficamten Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Topical Allopurinol Aloprim Reduced capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure and... Details Fluorouracil Topical Avatrombopag Doptelet Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Topical Azanidazole Increased exposure of 5-fluorouracil Details Fluorouracil Topical Benznidazole Increased exposure of 5-fluorouracil Details Fluorouracil Topical Carvedilol Coreg Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Topical Celecoxib Celebrex Increased celecoxib exposure and an increased risk of celecoxib-related adverse effects Details Fluorouracil Topical Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Fluorouracil Topical Cimetidine Tagamet An increased risk of fluorouracil toxicity Details Fluorouracil Topical Deuruxolitinib Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Topical Diclofenac Aleve Arthritis Pain Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Topical Dronabinol Marinol Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Topical Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Fluorouracil Topical Erdafitinib Balversa Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Topical Etrasimod Velsipity Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Topical Etravirine Intelence Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Topical Flurbiprofen Ansaid Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Topical Fluvastatin Lescol Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Topical Folic Acid Folacin Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Fluorouracil Topical Fosphenytoin Cerebyx Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and associated phenytoin or fosphenytoin toxicity Details Fluorouracil Topical Glimepiride Amaryl Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Topical Glipizide Glucotrol Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Topical Glyburide DiaBeta® Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Topical Ibuprofen Addaprin Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Fluorouracil Topical Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.