Fluoxetine

142 interactions 8 explained in plain English
Also sold as: RECONCILE
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Fluoxetine Dipyridamole Permole® An increased risk of bleeding Details Fluoxetine Disopyramide Norpace An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Dofetilide Tikosyn An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Dolasetron Anzemet Increased risk of serotonin syndrome and QT-interval prolongation Details Fluoxetine Dolasetron Injection Anzemet Increased risk of serotonin syndrome and QT-interval prolongation Details Fluoxetine Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Fluoxetine Edoxaban Savaysa An increased risk of bleeding Details Fluoxetine Encorafenib Braftovi Increased risk of QT interval prolongation Details Fluoxetine Enoxaparin Lovenox An increased risk of bleeding Details Fluoxetine Enoxaparin Injection Lovenox An increased risk of bleeding Details Fluoxetine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Fluoxetine Epoprostenol Flolan An increased risk of bleeding Details Fluoxetine Eribulin Injection Halaven An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Etodolac Lodine An increased risk of bleeding Details Fluoxetine Famotidine Calmicid An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Famotidine Injection Calmicid An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Felbamate Felbatol An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Fenoprofen Fenopron An increased risk of bleeding Details Fluoxetine Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Fluoxetine Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Fluoxetine Flecainide Tambocor® Increased flecainide exposure and an increased risk of QT interval prolongation Details Fluoxetine Flurbiprofen Ansaid An increased risk of bleeding Details Fluoxetine Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Fluoxetine Fondaparinux Arixtra An increased risk of bleeding Details Fluoxetine Fondaparinux Injection Arixtra An increased risk of bleeding Details Fluoxetine Foscarnet Injection Foscavir An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Fostemsavir Rukobia Increased risk of torsade de pointes Details Fluoxetine Galantamine Razadyne Increased galantamine exposure and an increased risk of QT interval prolongation Details Fluoxetine Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Gemifloxacin Factive An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Fluoxetine Gilteritinib Xospata Decreased effects of drugs that target the 5HT2B receptor or the sigma nonspecific receptor Details Fluoxetine Glasdegib Daurismo Increased risk of QT interval prolongation Details Fluoxetine Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Fluoxetine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome and QT-interval prolongation Details Fluoxetine Granisetron Injection Granisol Increased risk of serotonin syndrome and QT-interval prolongation Details Fluoxetine Heparin An increased risk of bleeding Details Fluoxetine Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Fluoxetine Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Fluoxetine Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Fluoxetine Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.