Fluoxetine

Name: Fluoxetine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

142 interactions 8 explained in plain English

Also sold as: RECONCILE

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Dolasetron Injection Loperamide Anagrelide Moxifloxacin Ophthalmic Palonosetron Injection

1 Contraindicated 130 Major 11 Moderate

All (142) Contraindicated (1) Major (130) Moderate (11)

Moderate

Fluoxetine Trospium / Xanomeline Cobenfy Explained Increased xanomeline exposure and an increased risk on severity and frequency of xanomeline-related adverse reactions Details Fluoxetine Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Fluoxetine Diazepam Nasal Spray Valtoco Increased diazePAM exposure Details Fluoxetine Diazepam Rectal Diastat Increased diazePAM exposure Details Fluoxetine Glimepiride Amaryl Excessive hypoglycemia Details Fluoxetine Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Fluoxetine Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Fluoxetine Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Increased risk of hypoglycemia Details Fluoxetine Insulin Detemir (Rdna Origin) Injection Levemir Increased risk of hypoglycemia Details Fluoxetine Insulin Glulisine (Rdna Origin) Injection Apidra Increased risk of hypoglycemia Details Fluoxetine Lumateperone Caplyta An increased risk for serotonin reuptake inhibitor (SRI)-associated adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.