Fluoxetine

142 interactions 8 explained in plain English
Also sold as: RECONCILE
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Fluoxetine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome, increased codeine exposure and reduced active metabolite (morphine) exposure Details Fluoxetine Amitriptyline Elavil Explained Increased risk of tricyclic antidepressant toxicity, QT interval prolongation and serotonin syndrome Details Fluoxetine Sertraline Explained Increased CYP2D6 substrate exposure, an increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Fluoxetine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation and an increased risk of serotonin syndrome Details Fluoxetine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Fluoxetine Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine-related toxicity Details Fluoxetine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Fluoxetine Apixaban Eliquis Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Fluoxetine Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Fluoxetine Aripiprazole Injection Abilify Increased ARIPiprazole exposure and an increased risk of QT interval prolongation Details Fluoxetine Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Fluoxetine Asenapine Transdermal Patch Secuado Increased FLUoxetine exposure, an increased asenapine exposure and an increased risk of QT interval prolongation Details Fluoxetine Aspirin Acuprin® An increased risk of bleeding Details Fluoxetine Aspirin Rectal Aspirin An increased risk of bleeding Details Fluoxetine Azithromycin AzaSite An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Betrixaban Bevyxxa® An increased risk of bleeding Details Fluoxetine Abiraterone Abirtega Increased FLUoxetine exposure and an increased risk of QT interval prolongation Details Fluoxetine Alfuzosin UroXatral An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Anagrelide Agrylin An increased risk of bleeding and an increased risk of QT interval prolongation Details Fluoxetine Bedaquiline Sirturo Increased bedaquiline exposure and an increased risk of QT interval prolongation Details Fluoxetine Brexpiprazole Rexulti Increased brexpiprazole exposure Details Fluoxetine Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Fluoxetine Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Fluoxetine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Fluoxetine Chloroquine Aralen® An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Clopidogrel Plavix Reduced exposure of the active metabolite of clopidogrel, reduced platelet inhibition and an increased risk of bleeding Details Fluoxetine Dabigatran Pradaxa® An increased risk of bleeding Details Fluoxetine Dabigatran Etexilate An increased risk of bleeding Details Fluoxetine Dacomitinib Vizimpro Increased FLUoxetine exposure and an increased risk of QT interval prolongation Details Fluoxetine Dalteparin Injection Fragmin An increased risk of bleeding Details Fluoxetine Dasatinib Phyrago An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Fluoxetine Deutetrabenazine Austedo Increased deutetrabenazine exposure; prolongation of QT interval Details Fluoxetine Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Fluoxetine Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Fluoxetine Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Fluoxetine Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Fluoxetine Digoxin Cardoxin® Increased digoxin exposure and an increased risk of digoxin toxicity (nausea, vomiting, arrhythmias) Details Fluoxetine Dihydroergotamine Injection DHE-45® Injection Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.