Fluoxetine

142 interactions 8 explained in plain English
Also sold as: RECONCILE
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Fluoxetine Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Fluoxetine Ibuprofen Addaprin An increased risk of bleeding Details Fluoxetine Iloprost Aurlumyn An increased risk of bleeding Details Fluoxetine Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Fluoxetine Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Fluoxetine Ivabradine Corlanor Increased risk of QT prolongation Details Fluoxetine Ketoconazole Topical Extina® Foam An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Ketoprofen Actron® An increased risk of bleeding Details Fluoxetine Ketorolac Acular An increased risk of bleeding Details Fluoxetine Ketorolac Injection Acular An increased risk of bleeding Details Fluoxetine Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Fluoxetine Ketorolac Ophthalmic Acular An increased risk of bleeding Details Fluoxetine Lefamulin Xenleta Increased risk of QT interval prolongation Details Fluoxetine Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Fluoxetine Levofloxacin Levaquin An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Levofloxacin Injection Levaquin An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Lithium Carbonate Lithobid An increased risk of serotonin syndrome Details Fluoxetine Loperamide Diamode Increased loperamide exposure, an increased risk of loperamide-related adverse effects and an increased risk of QT interval prolon... Details Fluoxetine Meclofenamate Meclodium® An increased risk of bleeding Details Fluoxetine Mefenamic Acid Ponstel® An increased risk of bleeding Details Fluoxetine Mefloquine Lariam® An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Fluoxetine Meloxicam Alloxate An increased risk of bleeding Details Fluoxetine Meloxicam Injection Alloxate An increased risk of bleeding Details Fluoxetine Methylergonovine Methergine Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Fluoxetine Methylphenidate Adhansia XR® Increased selective serotonin reuptake inhibitor exposure Details Fluoxetine Methylphenidate Transdermal Patch Daytrana Increased selective serotonin reuptake inhibitor exposure Details Fluoxetine Metoclopramide Injection Gimoti Increased metoclopramide exposure and risk of increased adverse events Details Fluoxetine Metoclopramide Nasal Spray Gimoti Increased metoclopramide exposure and risk of increased adverse events Details Fluoxetine Metronidazole Flagyl An increased risk of QT interval prolongation Details Fluoxetine Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Fluoxetine Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Fluoxetine Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Fluoxetine Mexiletine Mexitil® Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse events Details Fluoxetine Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Fluoxetine Moxifloxacin Avelox An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Moxifloxacin Injection Avelox An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Moxifloxacin Ophthalmic Moxeza® An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Nabumetone Relafen An increased risk of bleeding Details Fluoxetine Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details Fluoxetine Naproxen Aleve An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.