Fluoxetine

Name: Fluoxetine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

142 interactions 8 explained in plain English

Also sold as: RECONCILE

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Dolasetron Injection Loperamide Anagrelide Moxifloxacin Ophthalmic Palonosetron Injection

1 Contraindicated 130 Major 11 Moderate

All (142) Contraindicated (1) Major (130) Moderate (11)

Major

Fluoxetine Nebivolol Bystolic Increased exposure to nebivolol Details Fluoxetine Nifedipine Adalat® Increased NIFEdipine exposure Details Fluoxetine Octreotide Bynfezia An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Fluoxetine Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Fluoxetine Ofloxacin Floxin® An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Fluoxetine Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Fluoxetine Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details Fluoxetine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.