Drug Interaction Report

Flurbiprofen and Anisindione: Interaction Details

Name: Flurbiprofen and Anisindione Interaction
Creator: Dr. Brian Staiger, PharmD, BCPS

A pharmacist-reviewed analysis of the Flurbiprofen and Anisindione interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Flurbiprofen

Ansaid Ansaid® Lurbipr Lurbiro Ocufen

Anisindione

No brand names on record

Medically reviewed by

Dr. Brian Staiger, PharmD, BCPS

Updated Aug 8, 2026

Editorial policy · Data sources

Interaction severity

Moderate

Can be significant — usually manageable with monitoring.

Minor

Moderate

Major

Contraindicated

How we grade severity & evidence

Severity levels

Contraindicated: These should generally not be used together.
Major: Potentially serious — often needs a change or close monitoring.
Moderate: Can be significant — usually manageable with monitoring.
Minor: Usually limited clinical impact.

Evidence grades

Established: Well documented — supported by controlled studies or strong clinical data.
Probable: Good supporting evidence, though not definitively proven.
Suspected: Some evidence suggests this interaction, but it is not well established.
Possible: Limited or conflicting evidence; the interaction may occur.
Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 299 documented Flurbiprofen interactions, 60 are rated moderate — including this one.

Onset

delayed

Evidence

theoretical

Severity

Moderate

What happens

An increased risk of bleeding

Interaction Deep Dive

There have been a few reported cases of excessive hypoprothrombinemia and bleeding with concomitant use of flurbiprofen and acenocoumarol or phenprocoumon¹². Although not reported for anisindione, it is likely that a similar interaction could take place.

Why it happens (mechanism)

Gastric erosion, inhibition of platelet function

Common questions

Can I take Flurbiprofen and Anisindione together?

An increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.

How serious is the Flurbiprofen and Anisindione interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "delayed". Effects tend to build up gradually over days to weeks.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

Does my dose of Flurbiprofen or Anisindione need adjusting while I take them together?
What symptoms should prompt me to call you or my prescriber right away?
Does the timing of my doses matter for this combination?
Is there anything you'd monitor while I'm on both?

References (2)

Marbet GA, Duckert F, Walter M, et al: Interaction study between phenprocoumon and flurbiprofen. Curr Med Res Opin 1977; 5:26-31. PubMed
Stricker BH & Delhez JL: Interactions between flurbiprofen and coumarins. Br Med J 1982; 285:812-813. PubMed

Was this write-up helpful?

Flurbiprofen

Keep reading about Flurbiprofen

All Flurbiprofen interactions (299) Flurbiprofen drug information

Also serious with: Ketorolac Nasal Spray Ketorolac Ophthalmic Ketorolac Injection Ketorolac

Anisindione

Keep reading about Anisindione

All Anisindione interactions (43)

Also serious with: Aspirin Aspirin Rectal Danazol Fluoxymesterone

Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Flurbiprofen + Activated Charcoal Asarabacca Beer Siberian Cocklebur Wine Adrafinil African Wild Potato Alfalfa + 110 more

Anisindione + Activated Charcoal Danshen Piracetam Aconite Allspice Aloe Alpha-lipoic Acid Andrographis + 210 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

Check another combination

Our instant two-drug interaction checker is almost here.

Coming soon

The instant two-drug checker is on its way.

In the meantime, browse the directory below to look up any drug and see its documented interactions.

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

A message from HelloPharmacist

About our interaction database: depth, not breadth

HelloPharmacist doesn't license one of the big commercial interaction databases, so what you'll find here is not a complete list of every known drug interaction. Instead, each entry is researched, analyzed, and written up individually — documented from the published literature, reviewed by a pharmacist, and cited so you can check every source yourself.

If a combination isn't listed here, it means we haven't documented it yet — never that it's safe. For screening a full medication list, we recommend pairing this site with a comprehensive tool like the Drugs.com Interaction Checker and, most importantly, a review by your own pharmacist. For a deep, plain-English, fully sourced explanation of a specific documented interaction — that's exactly what we built this for.

This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.