Fluspirilene

20 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Esketamine Nasal Spray Buprenorphine Cabergoline Nalbuphine Injection Metoclopramide Injection Fentanyl Transdermal Patch
19 Major 1 Moderate
All (20) Major (19) Moderate (1)

Major

Fluspirilene Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Fluspirilene Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Fluspirilene Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Fluspirilene Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Fluspirilene Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Fluspirilene Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Fluspirilene Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Fluspirilene Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Fluspirilene Diazepam Rectal Diastat Increased risk of CNS depression Details Fluspirilene Esketamine Nasal Spray Spravato Increased risk of sedation Details Fluspirilene Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Fluspirilene Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Fluspirilene Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Fluspirilene Lacosamide Injection Motpoly An increased risk of CNS depression Details Fluspirilene Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Fluspirilene Metoclopramide Injection Gimoti Increased risk of CNS depression Details Fluspirilene Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Fluspirilene Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Fluspirilene Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Fluspirilene Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.