Fospropofol

21 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fentanyl Transdermal Patch Buprenorphine Nalbuphine Injection Morphine Injection Esketamine Nasal Spray Metoclopramide Injection
20 Major 1 Moderate
All (21) Major (20) Moderate (1)

Major

Fospropofol Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Fospropofol Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Fospropofol Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Fospropofol Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Fospropofol Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Fospropofol Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Fospropofol Diazepam Nasal Spray Valtoco Additive cardiorespiratory effects Details Fospropofol Diazepam Rectal Diastat Additive cardiorespiratory effects Details Fospropofol Esketamine Nasal Spray Spravato Increased risk of sedation Details Fospropofol Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Fospropofol Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Fospropofol Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Fospropofol Lacosamide Injection Motpoly An increased risk of CNS depression Details Fospropofol Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Fospropofol Metoclopramide Injection Gimoti Increased risk of CNS depression Details Fospropofol Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Fospropofol Midazolam Nasal Spray Nayzilam Additive cardiorespiratory effects Details Fospropofol Midazolam Injection Nayzilam Additive cardiorespiratory effects Details Fospropofol Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Fospropofol Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Fospropofol Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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