Furosemide Injection and Albuterol: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Albuterol
Furosemide Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of ECG changes or hypokalemia
Interaction Deep Dive
Use caution when coadministering albuterol with a potassium-depleting diuretic. Concomitant use of albuterol, a beta-adrenergic agonist, and a potassium-depleting diuretic, such as a thiazide or loop diuretic, may increase the risk of hypokalemia or ECG changes, especially with beta-agonist doses exceeding recommendations. Consider monitoring potassium levels during albuterol therapy12.
Why it happens (mechanism)
Potentiation of diuretic-induced ECG changes and hypokalemia by albuterol
Common questions
Can I take Furosemide Injection and Albuterol together?
An increased risk of ECG changes or hypokalemia Always confirm with your pharmacist or prescriber before making any change.
How serious is the Furosemide Injection and Albuterol interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Furosemide Injection or Albuterol need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: PROAIR(R) RESPICLICK(TM) oral inhalation powder, albuterol sulfate oral inhalation powder. Teva Respiratory, LLC (per manufacturer), Horsham, PA, 2015. DailyMed
- Product Information: AIRSUPRA(TM) oral inhalation aerosol, albuterol budesonide oral inhalation aerosol. AstraZeneca Pharmaceuticals LP (per FDA), Wilmington, DE, 2023. DailyMed
Keep reading about Albuterol
Keep reading about Furosemide Injection
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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