Ganaxolone

Name: Ganaxolone Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

30 interactions 2 explained in plain English

Also sold as: Ztalmy

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dexamethasone Injection Dexamethasone Ophthalmic Encorafenib Hydroxychloroquine Orlistat Nafcillin Injection

9 Major 21 Moderate

All (30) Major (9) Moderate (21)

Major

Ganaxolone Dexamethasone Injection Decadron Reduced ganaxolone exposure and reduced efficacy of ganaxolone Details Ganaxolone Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced ganaxolone exposure and reduced efficacy of ganaxolone Details Ganaxolone Encorafenib Braftovi Reduced ganaxolone exposure and reduced efficacy of ganaxolone Details Ganaxolone Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Ganaxolone Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Ganaxolone Mefenamic Acid Ponstel® Increased ganaxolone exposure and an increased risk of ganaxolone-related adverse reactions Details Ganaxolone Mitapivat Aqvesme Reduced ganaxolone exposure and reduced efficacy of ganaxolone Details Ganaxolone Nafcillin Injection Unipen® Injection Reduced ganaxolone exposure and reduced efficacy of ganaxolone Details Ganaxolone Orlistat Alli Reduced efficacy of anticonvulsant Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.