Gefitinib

60 interactions 147 cited references
Also sold as: Iressa Iressa®
About Gefitinib

Gefitinib is used to treat non-small cell lung cancer that has spread to other parts of the body in people with certain types of tumors. Gefitinib is in a class of medications called kinase inhibitors. It works by blocking the action of a certain naturally occurring substance that may be needed to help cancer cells mul… Read the full Gefitinib drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Typhoid Vaccine Measles Virus Vaccine, Live Smallpox Monkeypox Vaccine Mavorixafor Rubella Virus Vaccine, Live Yellow Fever Vaccine
10 Contraindicated 48 Major 2 Moderate
All (60) Contraindicated (10) Major (48) Moderate (2)

Contraindicated

Gefitinib Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Gefitinib Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Gefitinib Mavorixafor Xolremdi Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse events Details Gefitinib Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Gefitinib Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Gefitinib Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Gefitinib Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Gefitinib Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Gefitinib Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Gefitinib Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Gefitinib Omeprazole Gastrobim Decreased exposure of gefitinib Details Gefitinib Sertraline Increased CYP2D6 substrate exposure Details Gefitinib Asenapine Transdermal Patch Secuado Increased exposure of CYP2D6 substrate and inhibitor and an increased asenapine exposure Details Gefitinib Dexlansoprazole Dexilant Decreased exposure of gefitinib Details Gefitinib Esomeprazole Nexium Decreased exposure of gefitinib Details Gefitinib Esomeprazole Injection Nexium Decreased exposure of gefitinib Details Gefitinib Famotidine Calmicid Decreased exposure of gefitinib Details Gefitinib Famotidine Injection Calmicid Decreased exposure of gefitinib Details Gefitinib Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Gefitinib Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Gefitinib Aluminum Carbonate, Basic Decreased exposure of gefitinib Details Gefitinib Aluminum Hydroxide AlternaGEL® Decreased exposure of gefitinib Details Gefitinib Aluminum Phosphate Decreased exposure of gefitinib Details Gefitinib Asenapine Saphris Increased exposure of CYP2D6 substrate and inhibitor and an increased asenapine exposure Details Gefitinib Calcium Carbonate Alka-Mints Decreased exposure of gefitinib Details Gefitinib Carbamazepine Carbatrol Decreased exposure of gefitinib Details Gefitinib Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Gefitinib Cimetidine Tagamet Decreased exposure of gefitinib Details Gefitinib Clomipramine Anafranil Increased clomiPRAMINE exposure Details Gefitinib Dextroamphetamine Dexedrine Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Gefitinib Dihydroxyaluminum Aminoacetate Decreased exposure of gefitinib Details Gefitinib Dihydroxyaluminum Sodium Carbonate Decreased exposure of gefitinib Details Gefitinib Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Gefitinib Fosphenytoin Cerebyx Decreased exposure of gefitinib Details Gefitinib Haloperidol Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Gefitinib Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Gefitinib Itraconazole Sporanox Increased gefitinib exposure and an increased risk of gefitinib-related adverse effects Details Gefitinib Lansoprazole Prevacid Decreased exposure of gefitinib Details Gefitinib Lisdexamfetamine Arynta Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Gefitinib Lumefantrine Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse reactions Details

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