Gentamicin

19 interactions
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Aspirin Foscarnet Injection Furosemide Injection Cidofovir Injection Colistimethate Injection Cyclosporine Injection
11 Major 2 Moderate 6 Minor
All (19) Major (11) Moderate (2) Minor (6)

Major

Gentamicin Aspirin Acuprin® Increased aspirin exposure and an increased risk of nephrotoxicity Details Gentamicin Aspirin Rectal Aspirin Increased aspirin exposure and an increased risk of nephrotoxicity Details Gentamicin Cefepime Injection Maxipime® An increased risk of nephrotoxicity and an increased risk of ototoxicity Details Gentamicin Cidofovir Injection Vistide® Nephrotoxicity Details Gentamicin Colistimethate Injection Coly-Mycin M® Respiratory depression Details Gentamicin Cyclosporine Injection Atopica An increased risk of nephrotoxicity and increased risk of renal dysfunction Details Gentamicin Cyclosporine Ophthalmic Cequa An increased risk of nephrotoxicity and increased risk of renal dysfunction Details Gentamicin Digoxin Cardoxin® Increased digoxin exposure Details Gentamicin Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Gentamicin Foscarnet Injection Foscavir Nephrotoxicity Details Gentamicin Furosemide Injection Disal Increased gentamicin plasma and tissue concentrations and additive ototoxicity and/or nephrotoxicity Details

Moderate

Gentamicin Carboplatin Kyxata Ototoxicity Details Gentamicin Carboplatin Injection Kyxata Ototoxicity Details

Minor

Gentamicin Amoxicillin Amoxi Drop Loss of aminoglycoside efficacy Details Gentamicin Ampicillin Amcill® Loss of aminoglycoside efficacy Details Gentamicin Ampicillin Injection Omnipen-N® Loss of aminoglycoside efficacy Details Gentamicin Nafcillin Injection Unipen® Injection Loss of aminoglycoside efficacy Details Gentamicin Penicillin G Procaine Injection Bactracillin G Loss of aminoglycoside efficacy Details Gentamicin Penicillin V Potassium Beepen-VK® Loss of aminoglycoside efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.