Gepirone and Cyclosporine Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Gepirone
Cyclosporine Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased gepirone exposure and an increased risk of gepirone-related adverse effects
Interaction Deep Dive
Reduce the gepirone dose by 50% when used concomitantly with a moderate CYP3A4 inhibitor. Concomitant use of gepirone with moderate CYP3A4 inhibitors may increase the exposure of gepirone. In drug interaction studies, concomitant use of gepirone with verapamil 80 mg three times daily (a moderate CYP3A4 inhibitor) increased gepirone exposure by approximately 2.6-fold1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of gepirone
Literature reports
1 report — tap to read
a) In drug interaction studies, concomitant use of gepirone with a moderate CYP3A4 inhibitor (verapamil 80 mg three times daily) increased gepirone exposure by approximately 2.6-fold 1.
Common questions
Can I take Gepirone and Cyclosporine Injection together?
Increased gepirone exposure and an increased risk of gepirone-related adverse effects Always confirm with your pharmacist or prescriber before making any change.
How serious is the Gepirone and Cyclosporine Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Gepirone or Cyclosporine Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: EXXUA extended-release oral tablets, gepirone extended-release oral tablets. Mission Pharmaceutical Company (per FDA), San Antonio, TX, 2023. DailyMed
Keep reading about Gepirone
Keep reading about Cyclosporine Injection
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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