Gilteritinib

82 interactions 305 cited references
Also sold as: Xospata Xospata®
About Gilteritinib

Gilteritinib is used to treat a certain type of acute myeloid leukemia (AML) that has worsened or returned after treatment with other chemotherapy medications. Gilteritinib is in a class of medications called kinase inhibitors. It works by blocking the action of a certain naturally occurring substance that may be neede… Read the full Gilteritinib drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Gilteritinib Abametapir Increased exposure of CYP3A4 substrate Details Gilteritinib Sertraline Decreased effects of drugs that target the 5HT2B receptor or the sigma nonspecific receptor Details Gilteritinib Colchicine Colcrys Increased P-gp substrate exposure and increased incidence and severity of adverse reactions associated with the P-gp substrate Details Gilteritinib Capmatinib Tabrecta Increased P-gp substrate exposure and an increased risk of increased adverse reactions Details Gilteritinib Cyclosporine Injection Atopica Increased P-gp substrate exposure and increased incidence and severity of adverse reactions associated with the P-gp substrate Details Gilteritinib Cyclosporine Ophthalmic Cequa Increased P-gp substrate exposure and increased incidence and severity of adverse reactions associated with the P-gp substrate Details Gilteritinib Digoxin Cardoxin® Increased P-gp substrate exposure and increased incidence and severity of adverse reactions associated with the P-gp substrate Details Gilteritinib Dofetilide Tikosyn Increased OCT1 substrate exposure and increased incidence and severity of adverse reactions associated with the OCT1 substrate Details Gilteritinib Everolimus Afinitor Increased P-gp substrate exposure and increased incidence and severity of adverse reactions associated with the P-gp substrate Details Gilteritinib Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Gilteritinib Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Gilteritinib Apalutamide Erleada Reduced gilteritinib exposure Details Gilteritinib Avacopan Tavneos Increased CYP3A4 substrate exposure Details Gilteritinib Berotralstat Orladeyo Increased P-gp substrate exposure Details Gilteritinib Boceprevir Increased gilteritinib plasma concentrations Details Gilteritinib Carbamazepine Carbatrol Reduced gilteritinib exposure Details Gilteritinib Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Gilteritinib Clarithromycin Biaxin Increased gilteritinib plasma concentrations Details Gilteritinib Cobicistat Tybost Increased gilteritinib plasma concentrations Details Gilteritinib Conivaptan Vaprisol Increased CYP3A substrate exposure Details Gilteritinib Cyclosporine Atopica Increased P-gp substrate exposure and increased incidence and severity of adverse reactions associated with the P-gp substrate Details Gilteritinib Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Gilteritinib Erythromycin Erythrocin Stearate Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse effects Details Gilteritinib Escitalopram Lexapro Decreased effects of drugs that target the 5HT2B receptor or the sigma nonspecific receptor Details Gilteritinib Fedratinib Inrebic Increased CYP3A4 substrate exposure Details Gilteritinib Fexinidazole An increased CYP3A4 substrate exposure Details Gilteritinib Fluoxetine RECONCILE Decreased effects of drugs that target the 5HT2B receptor or the sigma nonspecific receptor Details Gilteritinib Fosphenytoin Cerebyx Reduced gilteritinib exposure Details Gilteritinib Idelalisib Zydelig Increased gilteritinib plasma concentrations Details Gilteritinib Indinavir Increased gilteritinib plasma concentrations Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.