Drug Interaction Report

Glyburide and Empagliflozin: Interaction Details

A pharmacist-reviewed analysis of the Glyburide and Empagliflozin interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Empagliflozin

Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Jardiance Jardiance® Synjardy® (as a combination product containing Empagliflozin and Metformin)
+

Glyburide

DiaBeta® Glynase Glynase® Micronase®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Moderate
Can be significant — usually manageable with monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 79 documented Glyburide interactions, 37 are rated moderate — including this one.
Onset
unspecified
Evidence
theoretical
Severity
Moderate

What happens

An increased risk of hypoglycemia

Interaction Deep Dive

Coadministration of empagliflozin and insulin secretagogues is associated with an increased risk of hypoglycemia. Coadministration may require a lower dose of the insulin secretagogue231. In a clinical trial there was a higher rate of hypoglycemia with empagliflozin in combination with an insulin secretagogue compared with placebo 3.

Why it happens (mechanism)

Additive hypoglycemia

Literature reports

1 report — tap to read

a) There was a higher rate of hypoglycemia with empagliflozin in combination with an insulin secretagogue compared with placebo in a clinical trial 3.

Common questions

Can I take Glyburide and Empagliflozin together?

An increased risk of hypoglycemia Always confirm with your pharmacist or prescriber before making any change.

How serious is the Glyburide and Empagliflozin interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Glyburide or Empagliflozin need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there anything you'd monitor while I'm on both?

References (3)

  1. Product Information: JARDIANCE(R) oral tablets, empagliflozin oral tablets. Boehringer Ingelheim Pharmaceuticals Inc (per FDA), Ridgefield, CT, 2021. DailyMed
  2. Product Information: SYNJARDY(R) oral tablets, empagliflozin metformin hydrochloride oral tablets. Boehringer Ingelheim Pharmaceuticals Inc (per FDA), Ridgefield, CT, 2025. DailyMed
  3. Product Information: GLYXAMBI(R) oral tablets, empagliflozin linagliptin oral tablets. Boehringer Ingelheim Pharmaceuticals Inc (per FDA), Ridgefield, CT, 2021. DailyMed
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Empagliflozin

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Glyburide

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Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Empagliflozin + Activated Charcoal Siberian Cocklebur Acai African Wild Potato Agaricus Mushroom Agmatine Agrimony Alfalfa + 249 more
Glyburide + Activated Charcoal Apple Beer Grapefruit Siberian Cocklebur Sweet Orange Wine Acai + 323 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.