Glycopyrronium Topical

97 interactions 49 cited references

Also sold as: Cuvposa® Qbrexza Qbrexza® Robinul® Robinul® Forte

About Glycopyrronium Topical

Topical glycopyrronium is used to treat excessive underarm sweating in adults and children 9 years of age and older. Topical glycopyrronium is in a class of medications called anticholinergics. It works by blocking the activity of a certain natural substance that triggers the sweat glands to produce sweat. Read the full Glycopyrronium Topical drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Potassium Chloride Potassium Citrate Umeclidinium Hydromorphone Hydrocodone Homatropine

2 Contraindicated 94 Major 1 Moderate

All (97) Contraindicated (2) Major (94) Moderate (1)

Contraindicated

Glycopyrronium Topical Potassium Chloride K-Tab Increased risk of gastrointestinal irritation Details Glycopyrronium Topical Potassium Citrate Urocit-K Increased risk of gastrointestinal irritation Details

Major

Glycopyrronium Topical Aclidinium Tudorza An increased risk of anticholinergic side effects Details Glycopyrronium Topical Alfentanil An increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Glycopyrronium Topical Amantadine Potentiation of anticholinergic effects Details Glycopyrronium Topical Amitriptyline Elavil An increased risk of anticholinergic side effects Details Glycopyrronium Topical Amoxapine An increased risk of anticholinergic side effects Details Glycopyrronium Topical Atropine Atropen An increased risk of anticholinergic side effects Details Glycopyrronium Topical Belladonna An increased risk of anticholinergic side effects Details Glycopyrronium Topical Benzhydrocodone Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Glycopyrronium Topical Benztropine An increased risk of anticholinergic side effects Details Glycopyrronium Topical Biperiden An increased risk of anticholinergic side effects Details Glycopyrronium Topical Brompheniramine Respa-BR An increased risk of anticholinergic side effects Details Glycopyrronium Topical Buprenorphine Belbuca An increased risk of paralytic ileus Details Glycopyrronium Topical Carbinoxamine Carbzah An increased risk of anticholinergic side effects Details Glycopyrronium Topical Carisoprodol Soma An increased risk of anticholinergic side effects Details Glycopyrronium Topical Chlorpheniramine An increased risk of anticholinergic side effects Details Glycopyrronium Topical Chlorpromazine An increased risk of anticholinergic side effects Details Glycopyrronium Topical Clemastine Clemasz An increased risk of anticholinergic side effects Details Glycopyrronium Topical Clidinium An increased risk of anticholinergic side effects Details Glycopyrronium Topical Clomipramine Anafranil An increased risk of anticholinergic side effects Details Glycopyrronium Topical Clozapine Clozaril An increased risk of anticholinergic side effects Details Glycopyrronium Topical Codeine Tuzistra XR® (as a combination product containing Chlorpheniramine, Codeine) An increased risk of paralytic ileus Details Glycopyrronium Topical Cyclobenzaprine Amrix An increased risk of anticholinergic side effects Details Glycopyrronium Topical Cyclopentolate Cyclogyl An increased risk of anticholinergic side effects Details Glycopyrronium Topical Cyproheptadine An increased risk of anticholinergic side effects Details Glycopyrronium Topical Darifenacin Enablex An increased risk of anticholinergic side effects Details Glycopyrronium Topical Desipramine Norpramin An increased risk of anticholinergic side effects Details Glycopyrronium Topical Dicyclomine Bentyl An increased risk of anticholinergic side effects Details Glycopyrronium Topical Dihydrocodeine Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Glycopyrronium Topical Dimenhydrinate Airmit An increased risk of anticholinergic side effects Details Glycopyrronium Topical Diphenhydramine Banophen An increased risk of anticholinergic side effects Details Glycopyrronium Topical Doxepin Prudoxin An increased risk of anticholinergic side effects Details Glycopyrronium Topical Fentanyl Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Glycopyrronium Topical Fesoterodine Toviaz An increased risk of anticholinergic side effects Details Glycopyrronium Topical Flavoxate An increased risk of anticholinergic side effects Details Glycopyrronium Topical Fluphenazine An increased risk of anticholinergic side effects Details Glycopyrronium Topical Glucagon Increased risk of gastrointestinal side effects Details Glycopyrronium Topical Glycopyrrolate Cuvposa An increased risk of anticholinergic side effects Details Glycopyrronium Topical Homatropine Homatropaire An increased risk of anticholinergic side effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.