Golimumab Injection and Infliximab: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Golimumab Injection
Infliximab
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased immunosuppression and an increased risk of infections
Interaction Deep Dive
The concomitant use of infliximab or infliximab biosimilar products with other biologic agents that treat the same conditions as infliximab is not recommended. Though this interaction has not been sufficiently studied, concomitant use may increase the risk of infection1.
Why it happens (mechanism)
Unknown
Common questions
Can I take Golimumab Injection and Infliximab together?
Increased immunosuppression and an increased risk of infections Always confirm with your pharmacist or prescriber before making any change.
How serious is the Golimumab Injection and Infliximab interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Golimumab Injection or Infliximab need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: REMICADE(R) intravenous injection, infliximab intravenous injection. Janssen Biotech Inc (per FDA), Horsham, PA, 2017. DailyMed
Keep reading about Golimumab Injection
Keep reading about Infliximab
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