Golimumab Injection and Vedolizumab: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Golimumab Injection
Vedolizumab
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of infections
Interaction Deep Dive
Avoid concomitant use of vedolizumab with TNF(Tumor Necrosis Factor) blockers due to the potential for increased risk of infections1.
Why it happens (mechanism)
Unknown
Common questions
Can I take Golimumab Injection and Vedolizumab together?
An increased risk of infections Always confirm with your pharmacist or prescriber before making any change.
How serious is the Golimumab Injection and Vedolizumab interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Golimumab Injection or Vedolizumab need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: ENTYVIO intravenous injection subcutaneous injection, vedolizumab intravenous injection subcutaneous injection. Takeda Pharmaceuticals America Inc (per FDA), Lexington, MA, 2023. DailyMed
Keep reading about Golimumab Injection
Keep reading about Vedolizumab
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