Gossypol

24 interactions
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Fenoprofen Meloxicam Mefenamic Acid Ketorolac Ophthalmic Diclofenac Topical (Arthritis Pain)
23 Major 1 Moderate
All (24) Major (23) Moderate (1)

Major

Gossypol Aspirin Acuprin® Increased risk of adverse gastrointestinal effects Details Gossypol Aspirin Rectal Aspirin Increased risk of adverse gastrointestinal effects Details Gossypol Bromfenac Ophthalmic Bromday® Increased risk of adverse gastrointestinal effects Details Gossypol Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of adverse gastrointestinal effects Details Gossypol Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of adverse gastrointestinal effects Details Gossypol Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of adverse gastrointestinal effects Details Gossypol Diclofenac Transdermal Patch Flector Increased risk of adverse gastrointestinal effects Details Gossypol Etodolac Lodine Increased risk of adverse gastrointestinal effects Details Gossypol Fenoprofen Fenopron Increased risk of adverse gastrointestinal effects Details Gossypol Flurbiprofen Ansaid Increased risk of adverse gastrointestinal effects Details Gossypol Flurbiprofen Ophthalmic Ocufen Increased risk of adverse gastrointestinal effects Details Gossypol Ibuprofen Addaprin Increased risk of adverse gastrointestinal effects Details Gossypol Ketoprofen Actron® Increased risk of adverse gastrointestinal effects Details Gossypol Ketorolac Acular Increased risk of adverse gastrointestinal effects Details Gossypol Ketorolac Injection Acular Increased risk of adverse gastrointestinal effects Details Gossypol Ketorolac Nasal Spray Sprix Increased risk of adverse gastrointestinal effects Details Gossypol Ketorolac Ophthalmic Acular Increased risk of adverse gastrointestinal effects Details Gossypol Meclofenamate Meclodium® Increased risk of adverse gastrointestinal effects Details Gossypol Mefenamic Acid Ponstel® Increased risk of adverse gastrointestinal effects Details Gossypol Meloxicam Alloxate Increased risk of adverse gastrointestinal effects Details Gossypol Meloxicam Injection Alloxate Increased risk of adverse gastrointestinal effects Details Gossypol Nabumetone Relafen Increased risk of adverse gastrointestinal effects Details Gossypol Naproxen Aleve Increased risk of adverse gastrointestinal effects Details

Moderate

Gossypol Furosemide Injection Disal Increased risk of hypokalemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.