Halobetasol Topical

21 interactions 132 cited references
Also sold as: Duobrii (as a combination product containing Halobetasol, Tazarotene) Lexette Lexette® Ultravate®
About Halobetasol Topical

Halobetasol topical is used to treat redness, swelling, itching, and discomfort of various skin conditions in adults and children 12 years of age and older, including plaque psoriasis (a skin disease in which red, scaly patches form on some areas of the body) and eczema (a skin disease that causes the skin to be dry an… Read the full Halobetasol Topical drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Mifepristone Aspirin Bemiparin Carbamazepine Cosyntropin
2 Contraindicated 13 Major 6 Moderate
All (21) Contraindicated (2) Major (13) Moderate (6)

Contraindicated

Halobetasol Topical Desmopressin DDAVP Increased risk of severe hyponatremia Details Halobetasol Topical Mifepristone Korlym An increased risk of autoimmune disorders and an increased risk of acute adrenal insufficiency, that may lead to exacerbation or d... Details

Major

Halobetasol Topical Aspirin Acuprin® An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Halobetasol Topical Bemiparin Increased risk of bleeding Details Halobetasol Topical Carbamazepine Carbatrol Reduced corticosteroids exposure and reduced efficacy of corticosteroids Details Halobetasol Topical Cosyntropin False elevations of plasma cortisol levels Details Halobetasol Topical Ethinyl Estradiol Increased corticosteroid exposure Details Halobetasol Topical Fosphenytoin Cerebyx Reduced corticosteroid exposure Details Halobetasol Topical Insulin Aspart, Recombinant Fiasp Reduced blood glucose lowering effect of insulin Details Halobetasol Topical Lutetium Lu 177 Dotatate Decreased lutetium Lu 177 dotatate efficacy Details Halobetasol Topical Nadroparin Increased risk of bleeding Details Halobetasol Topical Phenytoin Dilantin Reduced corticosteroid exposure Details Halobetasol Topical Sargramostim Leukine Increased myeloproliferative effects of sargramostim Details Halobetasol Topical Somatrogon-Ghla Reduced serum cortisol exposure, an increased risk of central (secondary) hypoadrenalism and attenuated growth-promoting effects o... Details Halobetasol Topical Upadacitinib Rinvoq Increased risk of gastrointestinal perforations Details

Moderate

Halobetasol Topical Auranofin Ridaura Increased risk of auranofin-related adverse effects Details Halobetasol Topical Gallium Ga 68 Dotatate Increased risk of false negative imaging Details Halobetasol Topical Insulin Afrezza Reduced blood glucose lowering effect of insulin Details Halobetasol Topical Insulin Lispro, Recombinant Admelog May decrease blood glucose lowering effect of insulin lispro Details Halobetasol Topical Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Halobetasol Topical Testosterone Androderm Increased risk of edema Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.