Halobetasol Topical

Name: Halobetasol Topical Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

21 interactions 132 cited references

Also sold as: Duobrii (as a combination product containing Halobetasol, Tazarotene) Lexette Lexette® Ultravate®

About Halobetasol Topical

Halobetasol topical is used to treat redness, swelling, itching, and discomfort of various skin conditions in adults and children 12 years of age and older, including plaque psoriasis (a skin disease in which red, scaly patches form on some areas of the body) and eczema (a skin disease that causes the skin to be dry an… Read the full Halobetasol Topical drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Mifepristone Aspirin Bemiparin Carbamazepine Cosyntropin

2 Contraindicated 13 Major 6 Moderate

All (21) Contraindicated (2) Major (13) Moderate (6)

Contraindicated

Halobetasol Topical Desmopressin DDAVP Increased risk of severe hyponatremia Details Halobetasol Topical Mifepristone Korlym An increased risk of autoimmune disorders and an increased risk of acute adrenal insufficiency, that may lead to exacerbation or d... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.