Homatropine

12 interactions 3 explained in plain English
Also sold as: Homatropaire
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Buprenorphine Fentanyl Transdermal Patch Glucagon Injection Glucagon Injection / Solution Glucagon Nasal Powder
11 Major 1 Moderate
All (12) Major (11) Moderate (1)

Major

Homatropine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of paralytic ileus Details Homatropine Buprenorphine Belbuca Explained An increased risk of paralytic ileus Details Homatropine Fentanyl Transdermal Patch Duragesic® Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Homatropine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Homatropine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Homatropine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Homatropine Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Homatropine Hydromorphone Injection Dilaudid Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Homatropine Hydromorphone Rectal available generically Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Homatropine Hydroxychloroquine Plaquenil An increased risk of seizures Details Homatropine Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, and paralytic ileus Details

Moderate

Homatropine Trospium / Xanomeline Cobenfy Explained An increased risk of anticholinergic adverse reactions (eg, dry mouth, constipation) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.