Hydralazine

Name: Hydralazine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

12 interactions 285 cited references

Also sold as: Apresoline® Dralzine®

About Hydralazine

Hydralazine is a vasodilator medication used to treat high blood pressure. Read the full Hydralazine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Clomipramine Dextroamphetamine Haloperidol Lisdexamfetamine Tramadol

5 Major 5 Moderate 2 Minor

All (12) Major (5) Moderate (5) Minor (2)

Major

Hydralazine Clomipramine Anafranil Increased clomiPRAMINE exposure Details Hydralazine Dextroamphetamine Dexedrine Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Hydralazine Haloperidol Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Hydralazine Lisdexamfetamine Arynta Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Hydralazine Tramadol ConZip Increased traMADol exposure and reduced exposure of the active metabolite Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.