Hydralazine

Name: Hydralazine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

12 interactions 285 cited references

Also sold as: Apresoline® Dralzine®

About Hydralazine

Hydralazine is a vasodilator medication used to treat high blood pressure. Read the full Hydralazine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Clomipramine Dextroamphetamine Haloperidol Lisdexamfetamine Tramadol

5 Major 5 Moderate 2 Minor

All (12) Major (5) Moderate (5) Minor (2)

Moderate

Hydralazine Indomethacin Indocin Decreased hydrALAZINE effectiveness Details Hydralazine Ma Huang Reduced hypotensive effect of hydrALAZINE Details Hydralazine Metoprolol Kapspargo Increased metoprolol concentrations Details Hydralazine Oxprenolol An increased risk of oxprenolol adverse effects (bradycardia, fatigue, bronchospasm) Details Hydralazine Yohimbine Reduced hydrALAZINE effectiveness Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.