Hydrocortisone Injection

393 interactions 735 cited references
Also sold as: A-Hydrocort® Ala-Cort Alkindi Alocane Anti-Itch Anucort-HC Anusol HC Aquanil HC Aquaphor Itch Relief Beta-HC Caldecort Cortaid Cortef Cortenema Cortizone Dermacort Dermtex HC Evesse Gynecort Hemmorex Hemorrodil Plus Hemril Instacort Kera-HC Khindivi Locoid MiCort-HC Monistat Itch Relief Pandel Procto-Med Procto-Pak Proctocort Proctosol Proctozone HC Recort Plus Sarnol-HC Scalpicin Itch Relief Solu-Cortef Solu-Cortef® Texacort U-Cort Vagisil Satin Westcort
About Hydrocortisone Injection

Hydrocortisone injection is used to treat symptoms of low corticosteroid levels (lack of certain substances that are usually produced by the body and are needed for normal body functioning). It is also used to treat severe allergic reactions. Hydrocortisone injection is used in the management of multiple sclerosis (a d… Read the full Hydrocortisone Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Ensitrelvir Mifepristone Piroxicam Warfarin Balsalazide Disodium
3 Contraindicated 140 Major 248 Moderate 2 Minor
All (393) Contraindicated (3) Major (140) Moderate (248) Minor (2)

Contraindicated

Hydrocortisone Injection Desmopressin DDAVP Increased risk of severe hyponatremia Details Hydrocortisone Injection Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Hydrocortisone Injection Mifepristone Korlym Increased CYP3A4 substrate exposure and an increased risk of autoimmune disorders and acute adrenal insufficiency, that may lead t... Details

Major

Hydrocortisone Injection Abametapir Increased exposure of CYP3A4 substrate Details Hydrocortisone Injection Aceclofenac Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Injection Acemetacin Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Injection Aldesleukin Proleukin Reduced antitumor effectiveness Details Hydrocortisone Injection Amtolmetin Guacil Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Injection Apalutamide Erleada Reduced CYP3A4 substrate exposure Details Hydrocortisone Injection Aspirin Acuprin® An increased risk of gastrointestinal adverse reactions; increased aspirin exposure and an increased risk of salicylism subsequent... Details Hydrocortisone Injection Atazanavir Reyataz Increased corticosteroid exposure and an increased risk of corticosteroid-related adverse effects Details Hydrocortisone Injection Avacopan Tavneos Increased CYP3A4 substrate exposure Details Hydrocortisone Injection Balofloxacin An increased risk of tendon rupture Details Hydrocortisone Injection Balsalazide Disodium An increased risk of gastrointestinal adverse reactions, reduced salicylate exposure and an increased risk of salicylate toxicity... Details Hydrocortisone Injection Bemiparin Increased risk of bleeding Details Hydrocortisone Injection Besifloxacin An increased risk of tendon rupture Details Hydrocortisone Injection Bromfenac Bromsite Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Injection Bufexamac Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Injection Bupropion Aplenzin Lowering of the seizure threshold Details Hydrocortisone Injection Carbamazepine Carbatrol Reduced hydrocortisone exposure and reduced efficacy of hydrocortisone Details Hydrocortisone Injection Celecoxib Celebrex Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Injection Choline Salicylate Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Injection Ciprofloxacin An increased risk of tendon rupture Details Hydrocortisone Injection Clarithromycin Biaxin Increased exposure of CYP3A4 substrate and risk for toxicity Details Hydrocortisone Injection Clonixin Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Injection Cobicistat Tybost Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Injection Conivaptan Vaprisol Increased CYP3A substrate exposure Details Hydrocortisone Injection Cosyntropin False elevations of plasma cortisol levels Details Hydrocortisone Injection Cyclosporine Atopica Increased hydrocortisone exposure, an increased cycloSPORINE exposure and an increased risk of convulsions Details Hydrocortisone Injection Darunavir Increased corticosteroid exposure Details Hydrocortisone Injection Desogestrel Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Hydrocortisone Injection Dexibuprofen Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Injection Dexketoprofen Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Injection Diclofenac Aleve Arthritis Pain Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Injection Dienogest Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Hydrocortisone Injection Diflunisal Dolobid Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Injection Dipyrone Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Injection Drospirenone Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Hydrocortisone Injection Droxicam Increased risk of gastrointestinal ulcer or bleeding Details Hydrocortisone Injection Enoxacin An increased risk of tendon rupture Details

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