Hydrocortisone

439 interactions 735 cited references

Also sold as: Ala-Cort Alkindi Alkindi Sprinkle® Alocane Anti-Itch Anucort-HC Anusol HC Aquanil HC Aquaphor Itch Relief Beta-HC Caldecort Cortaid Cortef Cortef® Cortenema Cortizone Cortril® Dermacort Dermtex HC Evesse Gynecort Hemmorex Hemorrodil Plus Hemril Hydrocortone® Instacort Kera-HC Khindivi Locoid MiCort-HC Monistat Itch Relief Pandel Procto-Med Procto-Pak Proctocort Proctosol Proctozone HC Recort Plus Sarnol-HC Scalpicin Itch Relief Solu-Cortef Texacort U-Cort Vagisil Satin Westcort

About Hydrocortisone

Hydrocortisone is a corticosteroid used to treat low steroid levels and conditions like arthritis, allergies, lupus, and inflammation affecting various body organs. Read the full Hydrocortisone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Desmopressin Nasal Ensitrelvir Mifepristone Levofloxacin Ofloxacin Otic

4 Contraindicated 167 Major 265 Moderate 3 Minor

All (439) Contraindicated (4) Major (167) Moderate (265) Minor (3)

Moderate

Hydrocortisone Relugolix Orgovyx Reduced hydrocortisone exposure Details Hydrocortisone Apixaban Eliquis Increased risk of gastrointestinal bleeding Details Hydrocortisone Asciminib Scemblix Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Auranofin Ridaura Increased risk of auranofin-related adverse effects Details Hydrocortisone Azithromycin AzaSite Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Belumosudil Rezurock Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Bicalutamide Casodex Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Atorvastatin Atorvaliq Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Amlodipine Amvaz® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Bexarotene Targretin Reduced hydrocortisone exposure Details Hydrocortisone Bexarotene Topical Targretin Reduced hydrocortisone exposure Details Hydrocortisone Brigatinib Alunbrig Reduced hydrocortisone exposure Details Hydrocortisone Brivaracetam Briviact Reduced hydrocortisone exposure Details Hydrocortisone Brivaracetam Injection Briviact Reduced hydrocortisone exposure Details Hydrocortisone Brodalumab Injection Siliq Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Clotrimazole Aardora Anti-Fungal Maximum Strength Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Clotrimazole Lozenge Mycelex® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Clotrimazole Topical Cruex Antifungal Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Clotrimazole Vaginal Gyne-Lotrimin 3® Cream Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Colestipol Colestid Decreased hydrocortisone effectiveness Details Hydrocortisone Dabigatran Pradaxa® Increased risk of gastrointestinal bleeding Details Hydrocortisone Dabigatran Etexilate Increased risk of gastrointestinal bleeding Details Hydrocortisone Darolutamide Nubeqa Reduced hydrocortisone exposure Details Hydrocortisone Dexamethasone Injection Decadron Reduced hydrocortisone exposure Details Hydrocortisone Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced hydrocortisone exposure Details Hydrocortisone Edoxaban Savaysa Increased risk of gastrointestinal bleeding Details Hydrocortisone Enasidenib Idhifa Reduced hydrocortisone exposure Details Hydrocortisone Encorafenib Braftovi Reduced hydrocortisone exposure Details Hydrocortisone Entrectinib Rozlytrek Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Erdafitinib Balversa Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Esketamine Nasal Spray Spravato Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Esomeprazole Nexium Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Esomeprazole Injection Nexium Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Everolimus Afinitor Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Fostamatinib Tavalisse Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Furosemide Injection Disal Hypokalemia Details Hydrocortisone Acenocoumarol Increased risk of bleeding or diminished effects of acenocoumarol Details Hydrocortisone Adagrasib Krazati Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Adenovirus Vaccine Type 4, Live An inadequate immunological response to the vaccine Details Hydrocortisone Adenovirus Vaccine Type 7, Live An inadequate immunological response to the vaccine Details

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