Hydrocortisone

439 interactions 735 cited references

Also sold as: Ala-Cort Alkindi Alkindi Sprinkle® Alocane Anti-Itch Anucort-HC Anusol HC Aquanil HC Aquaphor Itch Relief Beta-HC Caldecort Cortaid Cortef Cortef® Cortenema Cortizone Cortril® Dermacort Dermtex HC Evesse Gynecort Hemmorex Hemorrodil Plus Hemril Hydrocortone® Instacort Kera-HC Khindivi Locoid MiCort-HC Monistat Itch Relief Pandel Procto-Med Procto-Pak Proctocort Proctosol Proctozone HC Recort Plus Sarnol-HC Scalpicin Itch Relief Solu-Cortef Texacort U-Cort Vagisil Satin Westcort

About Hydrocortisone

Hydrocortisone is a corticosteroid used to treat low steroid levels and conditions like arthritis, allergies, lupus, and inflammation affecting various body organs. Read the full Hydrocortisone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Desmopressin Nasal Ensitrelvir Mifepristone Levofloxacin Ofloxacin Otic

4 Contraindicated 167 Major 265 Moderate 3 Minor

All (439) Contraindicated (4) Major (167) Moderate (265) Minor (3)

Moderate

Hydrocortisone Alcuronium Decreased alcuronium effectiveness; prolonged muscle weakness and myopathy Details Hydrocortisone Alprazolam Xanax Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Amiodarone Nexterone Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Amprenavir Altered (increased/reduced) hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Aprepitant Aponvie Altered (increased/reduced) hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Armodafinil Nuvigil Reduced hydrocortisone exposure Details Hydrocortisone Artemether Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Hydrocortisone Atracurium Decreased atracurium effectiveness; prolonged muscle weakness and myopathy Details Hydrocortisone Bacillus Of Calmette And Guerin Vaccine, Live An inadequate immunological response to the vaccine Details Hydrocortisone Belzutifan Welireg Reduced hydrocortisone exposure Details Hydrocortisone Berberine Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Berotralstat Orladeyo Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Boceprevir Altered (increased/reduced) hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Bosentan Reduced hydrocortisone exposure Details Hydrocortisone Brodalumab Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Cannabis Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Capivasertib Truqap Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Cenobamate Xcopri Reduced hydrocortisone exposure Details Hydrocortisone Ceritinib Zykadia Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Chlorthalidone Hemiclor Hypokalemia Details Hydrocortisone Chlorzoxazone Lorzone Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Cholera Vaccine, Live An inadequate immunological response to the vaccine Details Hydrocortisone Cilostazol Pletal® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Cimetidine Tagamet Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Cisatracurium Decreased cisatracurium effectiveness; prolonged muscle weakness and myopathy Details Hydrocortisone Clobazam Onfi Reduced hydrocortisone exposure Details Hydrocortisone Clofazimine Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Crizotinib Xalkori Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Dabigatran Etexilate Mesylate Increased risk of gastrointestinal bleeding Details Hydrocortisone Dabrafenib Tafinlar Reduced hydrocortisone exposure Details Hydrocortisone Daclatasvir Daklinza® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Daridorexant Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Delavirdine Rescriptor® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Dengue Tetravalent Vaccine, Live An inadequate immunological response to the vaccine Details Hydrocortisone Dexamethasone Reduced hydrocortisone exposure Details Hydrocortisone Dicloxacillin Reduced hydrocortisone exposure Details Hydrocortisone Dicumarol Increased risk of bleeding or diminished effects of dicumarol Details Hydrocortisone Diltiazem Cardizem Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Diosmin Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Doxacurium Decreased doxacurium effectiveness; prolonged muscle weakness and myopathy Details

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