Hydrocortisone

439 interactions 735 cited references

Also sold as: Ala-Cort Alkindi Alkindi Sprinkle® Alocane Anti-Itch Anucort-HC Anusol HC Aquanil HC Aquaphor Itch Relief Beta-HC Caldecort Cortaid Cortef Cortef® Cortenema Cortizone Cortril® Dermacort Dermtex HC Evesse Gynecort Hemmorex Hemorrodil Plus Hemril Hydrocortone® Instacort Kera-HC Khindivi Locoid MiCort-HC Monistat Itch Relief Pandel Procto-Med Procto-Pak Proctocort Proctosol Proctozone HC Recort Plus Sarnol-HC Scalpicin Itch Relief Solu-Cortef Texacort U-Cort Vagisil Satin Westcort

About Hydrocortisone

Hydrocortisone is a corticosteroid used to treat low steroid levels and conditions like arthritis, allergies, lupus, and inflammation affecting various body organs. Read the full Hydrocortisone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Desmopressin Nasal Ensitrelvir Mifepristone Levofloxacin Ofloxacin Otic

4 Contraindicated 167 Major 265 Moderate 3 Minor

All (439) Contraindicated (4) Major (167) Moderate (265) Minor (3)

Moderate

Hydrocortisone Dronedarone Multaq Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Duvelisib Copiktra Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Ebola Zaire Vaccine, Live An inadequate immunological response to the vaccine Details Hydrocortisone Echinacea Decreased effectiveness of corticosteroids Details Hydrocortisone Efavirenz Reduced hydrocortisone exposure Details Hydrocortisone Elafibranor Iqirvo Reduced hydrocortisone exposure Details Hydrocortisone Elagolix Orilissa Reduced hydrocortisone exposure Details Hydrocortisone Enzalutamide Xtandi Reduced hydrocortisone exposure Details Hydrocortisone Erythromycin Erythrocin Stearate Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Esketamine Spravato Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Eslicarbazepine Acetate Aptiom Reduced hydrocortisone exposure Details Hydrocortisone Ethacrynic Acid Edecrin Hypokalemia Details Hydrocortisone Etravirine Intelence Reduced hydrocortisone exposure Details Hydrocortisone Flibanserin Addyi Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Fluconazole Diflucan Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Fluindione Increased risk of bleeding or diminished effects of fluindione Details Hydrocortisone Fluoxetine RECONCILE Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Fluvoxamine Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Fosamprenavir Lexiva Altered (increased/reduced) hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Fosaprepitant Emend Injection Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Furosemide Disal Hypokalemia Details Hydrocortisone Gallamine Decreased gallamine effectiveness; prolonged muscle weakness and myopathy Details Hydrocortisone Gallium Ga 68 Dotatate Increased risk of false negative imaging Details Hydrocortisone Garlic Reduced hydrocortisone exposure Details Hydrocortisone Gepotidacin Blujepa Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Ginkgo Altered (increased/reduced) hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Ginseng Reduced hydrocortisone exposure Details Hydrocortisone Givinostat Duvyzat Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Glecaprevir Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Goldenseal Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Grazoprevir Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Haemophilus B Vaccine An inadequate immunological response to the vaccine Details Hydrocortisone Hepatitis A Vaccine, Inactivated An inadequate immunological response to the vaccine Details Hydrocortisone Hexafluorenium Decreased hexafluorenium bromide effectiveness; prolonged muscle weakness and myopathy Details Hydrocortisone Hydrochlorothiazide Inzirqo Hypokalemia and subsequent cardiac arrhythmias Details Hydrocortisone Ibrexafungerp Brexafemme Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Idelalisib Zydelig Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Imatinib Gleevec Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Indapamide An increased risk of hypokalemia Details Hydrocortisone Indinavir Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details

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