Hydrocortisone

439 interactions 735 cited references

Also sold as: Ala-Cort Alkindi Alkindi Sprinkle® Alocane Anti-Itch Anucort-HC Anusol HC Aquanil HC Aquaphor Itch Relief Beta-HC Caldecort Cortaid Cortef Cortef® Cortenema Cortizone Cortril® Dermacort Dermtex HC Evesse Gynecort Hemmorex Hemorrodil Plus Hemril Hydrocortone® Instacort Kera-HC Khindivi Locoid MiCort-HC Monistat Itch Relief Pandel Procto-Med Procto-Pak Proctocort Proctosol Proctozone HC Recort Plus Sarnol-HC Scalpicin Itch Relief Solu-Cortef Texacort U-Cort Vagisil Satin Westcort

About Hydrocortisone

Hydrocortisone is a corticosteroid used to treat low steroid levels and conditions like arthritis, allergies, lupus, and inflammation affecting various body organs. Read the full Hydrocortisone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Desmopressin Nasal Ensitrelvir Mifepristone Levofloxacin Ofloxacin Otic

4 Contraindicated 167 Major 265 Moderate 3 Minor

All (439) Contraindicated (4) Major (167) Moderate (265) Minor (3)

Moderate

Hydrocortisone Influenza Virus Vaccine An inadequate immunological response to the vaccine Details Hydrocortisone Insulin Afrezza Reduced blood glucose lowering effect of insulin Details Hydrocortisone Insulin Lispro, Recombinant Admelog May decrease blood glucose lowering effect of insulin lispro Details Hydrocortisone Isavuconazole Altered (increased/reduced) hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Isavuconazonium Cresemba Altered (increased/reduced) hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Isoniazid Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Istradefylline Nourianz Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Ivacaftor Kalydeco Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Ivosidenib Tibsovo Reduced hydrocortisone exposure Details Hydrocortisone Ketoconazole Extina Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Kratom Increased CYP3A substrate exposure Details Hydrocortisone Lapatinib Tykerb Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Larotrectinib Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Lazertinib Lazcluze Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Lefamulin Xenleta Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Lesinurad Reduced hydrocortisone exposure Details Hydrocortisone Licorice Increased risk of corticosteroid adverse effects Details Hydrocortisone Linagliptin Tradjenta Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Lomitapide Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Lonafarnib Zokinvy Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Lopinavir Reduced hydrocortisone exposure Details Hydrocortisone Lorlatinib Lorbrena Reduced hydrocortisone exposure Details Hydrocortisone Lumacaftor Reduced hydrocortisone exposure Details Hydrocortisone Lumateperone Caplyta Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Lurasidone Latuda Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Ma Huang Decreased effectiveness of corticosteroids Details Hydrocortisone Maribavir Livtencity Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Mavacamten Camzyos Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Hydrocortisone Mavorixafor Xolremdi Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Measles Virus Vaccine, Live An inadequate immunological response to the vaccine Details Hydrocortisone Meningococcal Vaccine An inadequate immunological response to the vaccine Details Hydrocortisone Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Hydrocortisone Methylprednisolone Depo-Medrol Reduced hydrocortisone exposure Details Hydrocortisone Metocurine Decreased metocurine effectiveness; prolonged muscle weakness and myopathy Details Hydrocortisone Mitapivat Aqvesme Reduced hydrocortisone exposure Details Hydrocortisone Mitotane Lysodren Reduced hydrocortisone exposure Details Hydrocortisone Mivacurium Decreased mivacurium effectiveness; prolonged muscle weakness and myopathy Details Hydrocortisone Mobocertinib Exkivity Reduced hydrocortisone exposure Details Hydrocortisone Modafinil Provigil Reduced hydrocortisone exposure Details Hydrocortisone Mumps Virus Vaccine, Live An inadequate immunological response to the vaccine Details

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