Hydrocortisone

439 interactions 735 cited references

Also sold as: Ala-Cort Alkindi Alkindi Sprinkle® Alocane Anti-Itch Anucort-HC Anusol HC Aquanil HC Aquaphor Itch Relief Beta-HC Caldecort Cortaid Cortef Cortef® Cortenema Cortizone Cortril® Dermacort Dermtex HC Evesse Gynecort Hemmorex Hemorrodil Plus Hemril Hydrocortone® Instacort Kera-HC Khindivi Locoid MiCort-HC Monistat Itch Relief Pandel Procto-Med Procto-Pak Proctocort Proctosol Proctozone HC Recort Plus Sarnol-HC Scalpicin Itch Relief Solu-Cortef Texacort U-Cort Vagisil Satin Westcort

About Hydrocortisone

Hydrocortisone is a corticosteroid used to treat low steroid levels and conditions like arthritis, allergies, lupus, and inflammation affecting various body organs. Read the full Hydrocortisone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Desmopressin Nasal Ensitrelvir Mifepristone Levofloxacin Ofloxacin Otic

4 Contraindicated 167 Major 265 Moderate 3 Minor

All (439) Contraindicated (4) Major (167) Moderate (265) Minor (3)

Moderate

Hydrocortisone Nafcillin Reduced hydrocortisone exposure Details Hydrocortisone Nefazodone Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Nelfinavir Viracept Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Neostigmine Decreased neostigmine effectiveness Details Hydrocortisone Nevirapine Viramune Reduced hydrocortisone exposure Details Hydrocortisone Nilotinib Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Nirogacestat Ogsiveo Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Olaparib Lynparza Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Olodaterol Striverdi An increased risk of hypokalemia Details Hydrocortisone Oritavancin Reduced hydrocortisone exposure Details Hydrocortisone Osilodrostat Isturisa Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Oxcarbazepine Oxtellar Reduced hydrocortisone exposure Details Hydrocortisone Palbociclib Ibrance Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Pancuronium Decreased pancuronium effectiveness; prolonged muscle weakness and myopathy Details Hydrocortisone Paritaprevir Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Pazopanib Votrient Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Peppermint Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Pexidartinib Turalio Reduced hydrocortisone exposure Details Hydrocortisone Phenprocoumon Increased risk of bleeding or diminished effects of phenprocoumon Details Hydrocortisone Pibrentasvir Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Pioglitazone Actos Reduced hydrocortisone exposure Details Hydrocortisone Pipecuronium Decreased pipecuronium effectiveness; prolonged muscle weakness and myopathy Details Hydrocortisone Piperine Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Pirtobrutinib Jaypirca Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Pitolisant Wakix Reduced hydrocortisone exposure Details Hydrocortisone Pneumococcal Vaccine An inadequate immunological response to the vaccine Details Hydrocortisone Pneumococcal Vaccine, Diphtheria Conjugate An inadequate immunological response to the vaccine Details Hydrocortisone Pneumococcal Vaccine Polyvalent An inadequate immunological response to the vaccine Details Hydrocortisone Poliovirus Vaccine, Live An inadequate immunological response to the vaccine Details Hydrocortisone Posaconazole Noxafil Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Prednisone Deltasone Reduced hydrocortisone exposure Details Hydrocortisone Pretomanid Reduced hydrocortisone exposure Details Hydrocortisone Propofol Diprivan Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Pyridostigmine Mestinon Decreased pyridostigmine effectiveness Details Hydrocortisone Quercetin Reduced hydrocortisone exposure Details Hydrocortisone Rabies Vaccine Imovax An inadequate immunological response to the vaccine Details Hydrocortisone Raltegravir Isentress Reduced hydrocortisone exposure Details Hydrocortisone Ranitidine Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Ranolazine Aspruzyo Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Repotrectinib Augtyro Reduced hydrocortisone exposure Details

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