Hydrocortisone

439 interactions 735 cited references

Also sold as: Ala-Cort Alkindi Alkindi Sprinkle® Alocane Anti-Itch Anucort-HC Anusol HC Aquanil HC Aquaphor Itch Relief Beta-HC Caldecort Cortaid Cortef Cortef® Cortenema Cortizone Cortril® Dermacort Dermtex HC Evesse Gynecort Hemmorex Hemorrodil Plus Hemril Hydrocortone® Instacort Kera-HC Khindivi Locoid MiCort-HC Monistat Itch Relief Pandel Procto-Med Procto-Pak Proctocort Proctosol Proctozone HC Recort Plus Sarnol-HC Scalpicin Itch Relief Solu-Cortef Texacort U-Cort Vagisil Satin Westcort

About Hydrocortisone

Hydrocortisone is a corticosteroid used to treat low steroid levels and conditions like arthritis, allergies, lupus, and inflammation affecting various body organs. Read the full Hydrocortisone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Desmopressin Nasal Ensitrelvir Mifepristone Levofloxacin Ofloxacin Otic

4 Contraindicated 167 Major 265 Moderate 3 Minor

All (439) Contraindicated (4) Major (167) Moderate (265) Minor (3)

Moderate

Hydrocortisone Resveratrol Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Ribociclib Kisqali Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Rifabutin Mycobutin Reduced hydrocortisone exposure Details Hydrocortisone Rifampin Rifadin Reduced hydrocortisone exposure Details Hydrocortisone Rifapentine Priftin Decreased corticosteroid effectiveness Details Hydrocortisone Rilzabrutinib Wayrilz Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Hydrocortisone Rimegepant Nurtec Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Ritlecitinib Litfulo Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Ritonavir Norvir Altered (increased/reduced) hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Rivaroxaban Xarelto Increased risk of gastrointestinal bleeding Details Hydrocortisone Rocuronium Decreased rocuronium effectiveness; prolonged muscle weakness and myopathy Details Hydrocortisone Rotavirus Vaccine, Live An inadequate immunological response to the vaccine Details Hydrocortisone Rubella Virus Vaccine, Live An inadequate immunological response to the vaccine Details Hydrocortisone Rucaparib Rubraca Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Rufinamide Banzel Reduced hydrocortisone exposure Details Hydrocortisone Safinamide Xadago Reduced hydrocortisone exposure Details Hydrocortisone Saiboku-To Enhanced and prolonged effect of corticosteroids Details Hydrocortisone Saquinavir Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Sarilumab Reduced hydrocortisone exposure Details Hydrocortisone Schizandra Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Selpercatinib Retevmo Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Simeprevir Olysio® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Smallpox Monkeypox Vaccine An inadequate immunological response to the vaccine Details Hydrocortisone Sotagliflozin Inpefa Reduced hydrocortisone exposure Details Hydrocortisone Sotorasib Lumakras Reduced hydrocortisone exposure Details Hydrocortisone St John's Wort Reduced hydrocortisone exposure Details Hydrocortisone Sulfinpyrazone Reduced hydrocortisone exposure Details Hydrocortisone Suvorexant Belsomra Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Tecovirimat Reduced hydrocortisone exposure Details Hydrocortisone Telaprevir Altered (increased/reduced) hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Telithromycin Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Telotristat Ethyl Xermelo Reduced hydrocortisone exposure Details Hydrocortisone Terbinafine Lamisil Reduced hydrocortisone exposure Details Hydrocortisone Teriflunomide Aubagio Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Testosterone Androderm Increased risk of edema Details Hydrocortisone Tetanus Toxoid An inadequate immunological response to the vaccine Details Hydrocortisone Thioridazine Reduced hydrocortisone exposure Details Hydrocortisone Ticagrelor Brilinta Altered (increased/reduced) hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Ticlopidine Ticlid® Reduced hydrocortisone exposure Details Hydrocortisone Tolvaptan Jynarque Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details

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