Hydrocortisone

439 interactions 735 cited references
Also sold as: Ala-Cort Alkindi Alkindi Sprinkle® Alocane Anti-Itch Anucort-HC Anusol HC Aquanil HC Aquaphor Itch Relief Beta-HC Caldecort Cortaid Cortef Cortef® Cortenema Cortizone Cortril® Dermacort Dermtex HC Evesse Gynecort Hemmorex Hemorrodil Plus Hemril Hydrocortone® Instacort Kera-HC Khindivi Locoid MiCort-HC Monistat Itch Relief Pandel Procto-Med Procto-Pak Proctocort Proctosol Proctozone HC Recort Plus Sarnol-HC Scalpicin Itch Relief Solu-Cortef Texacort U-Cort Vagisil Satin Westcort
About Hydrocortisone

Hydrocortisone is a corticosteroid used to treat low steroid levels and conditions like arthritis, allergies, lupus, and inflammation affecting various body organs. Read the full Hydrocortisone drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Desmopressin Nasal Ensitrelvir Mifepristone Levofloxacin Ofloxacin Otic
4 Contraindicated 167 Major 265 Moderate 3 Minor
All (439) Contraindicated (4) Major (167) Moderate (265) Minor (3)

Moderate

Hydrocortisone Topiramate Eprontia Reduced hydrocortisone exposure Details Hydrocortisone Tovorafenib Ojemda Reduced hydrocortisone exposure Details Hydrocortisone Treosulfan Grafapex Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Tretinoin Altreno Decreased efficacy of tretinoin Details Hydrocortisone Trofinetide Daybue Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Troglitazone Reduced hydrocortisone exposure Details Hydrocortisone Troleandomycin Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Tubocurarine Decreased tubocurarine effectiveness; prolonged muscle weakness and myopathy Details Hydrocortisone Tucatinib Tukysa Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Typhoid Vaccine, Live Vivotif An inadequate immunological response to the vaccine Details Hydrocortisone Varicella Virus Vaccine, Live An inadequate immunological response to the vaccine Details Hydrocortisone Vecuronium Decreased vecuronium effectiveness; prolonged muscle weakness and myopathy Details Hydrocortisone Vemurafenib Zelboraf Reduced hydrocortisone exposure Details Hydrocortisone Verapamil Calan Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Viloxazine Qelbree Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Vinblastine Velban® Reduced hydrocortisone exposure Details Hydrocortisone Vonoprazan Voquezna Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Voxelotor Oxbryta Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Yellow Fever Vaccine Stamaril An inadequate immunological response to the vaccine Details Hydrocortisone Zanubrutinib Brukinsa Reduced hydrocortisone exposure Details Hydrocortisone Zoster Vaccine, Live An inadequate immunological response to the vaccine Details Hydrocortisone Ketoconazole Topical Extina® Foam Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Hydrocortisone Nafcillin Injection Unipen® Injection Reduced hydrocortisone exposure Details Hydrocortisone Neostigmine Methylsulfate Bloxiverz Decreased neostigmine effectiveness Details Hydrocortisone Olodaterol Oral Inhalation Striverdi An increased risk of hypokalemia Details

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