Hydromorphone
43 interactions 5 explained in plain English
Also sold as:
Dilaudid
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Lithium Carbonate
Esketamine Nasal Spray
Metoclopramide Nasal Spray
Palonosetron Injection
Metoclopramide Injection
Cetirizine Injection
Major
Hydromorphone Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Hydromorphone Amitriptyline Elavil Explained Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Hydromorphone Sertraline Explained Increased risk of serotonin syndrome Details Hydromorphone Buprenorphine Belbuca Explained Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Hydromorphone Trospium / Xanomeline Cobenfy Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Aripiprazole Injection Abilify Increased risk of respiratory and CNS depression Details Hydromorphone Asenapine Transdermal Patch Secuado Increased risk of respiratory and CNS depression Details Hydromorphone Aclidinium Oral Inhalation Tudorza Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Atropine Ophthalmic Atropine Care 1% Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Butorphanol Injection Butorphic Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Hydromorphone Butorphanol Nasal Spray Stadol® NS Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Hydromorphone Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Hydromorphone Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Hydromorphone Clopidogrel Plavix Reduced efficacy of clopidogrel Details Hydromorphone Cyclopentolate Ophthalmic Akpentolate® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Diazepam Nasal Spray Valtoco Increased risk of respiratory and CNS depression Details Hydromorphone Diazepam Rectal Diastat Increased risk of respiratory and CNS depression Details Hydromorphone Diphenhydramine Injection Banophen Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Hydromorphone Diphenhydramine Topical Afterbite with Antihistamine Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Hydromorphone Dolasetron Anzemet Increased risk of serotonin syndrome Details Hydromorphone Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Hydromorphone Esketamine Nasal Spray Spravato Increased risk of sedation Details Hydromorphone Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Hydromorphone Furosemide Injection Disal Reduced efficacy of diuretics Details Hydromorphone Glycopyrronium Topical Cuvposa® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Hydromorphone Granisetron Injection Granisol Increased risk of serotonin syndrome Details Hydromorphone Hydroxychloroquine Plaquenil An increased risk of seizures Details Hydromorphone Ipratropium Nasal Spray Atrovent Nasal Spray® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Ipratropium Oral Inhalation Atrovent® HFA Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Lacosamide Injection Motpoly An increased risk of CNS depression Details Hydromorphone Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Hydromorphone Linezolid Injection Zyvox Increased risk of serotonin syndrome or opioid toxicity Details Hydromorphone Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Hydromorphone Metoclopramide Injection Gimoti Increased risk of CNS depression Details Hydromorphone Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Hydromorphone Midazolam Nasal Spray Nayzilam Increased risk of respiratory and CNS depression Details Hydromorphone Midazolam Injection Nayzilam Increased risk of respiratory and CNS depression Details Hydromorphone Morphine Injection Astramorph® PF Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Hydromorphone Nalbuphine Injection Nubain® Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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