Drug Interaction Report

Hydromorphone Rectal and Valerian: Interaction Details

Name: Hydromorphone Rectal and Valerian Interaction
Creator: Dr. Brian Staiger, PharmD, BCPS

A pharmacist-reviewed analysis of the Hydromorphone Rectal and Valerian interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Valerian

No brand names on record

Hydromorphone Rectal

available generically

Medically reviewed by

Dr. Brian Staiger, PharmD, BCPS

Updated Aug 8, 2026

Editorial policy · Data sources

Interaction severity

Moderate

Can be significant — usually manageable with monitoring.

Minor

Moderate

Major

Contraindicated

How we grade severity & evidence

Severity levels

Contraindicated: These should generally not be used together.
Major: Potentially serious — often needs a change or close monitoring.
Moderate: Can be significant — usually manageable with monitoring.
Minor: Usually limited clinical impact.

Evidence grades

Established: Well documented — supported by controlled studies or strong clinical data.
Probable: Good supporting evidence, though not definitively proven.
Suspected: Some evidence suggests this interaction, but it is not well established.
Possible: Limited or conflicting evidence; the interaction may occur.
Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 344 documented Hydromorphone Rectal interactions, 9 are rated moderate — including this one.

Onset

unspecified

Evidence

theoretical

Severity

Moderate

What happens

Additive central nervous system depression

Interaction Deep Dive

Valerian induced sedation by modulating gamma aminobutyric acid neurotransmission, in animal studies. When used concomitantly with opioid analgesics, additive CNS and respiratory depression may occur. Caution is advised whenever valerian and an opiate are used in combination¹.

Why it happens (mechanism)

Modulation of gamma aminobutyric acid neurotransmission and receptor function

Common questions

Can I take Hydromorphone Rectal and Valerian together?

Additive central nervous system depression Always confirm with your pharmacist or prescriber before making any change.

How serious is the Hydromorphone Rectal and Valerian interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

From our Q&A

Real reader questions about these medications, each personally answered by our pharmacist:

Can Valerian or Lavender Help Sleep While on Simvastatin?

Questions for your pharmacist

Does my dose of Hydromorphone Rectal or Valerian need adjusting while I take them together?
What symptoms should prompt me to call you or my prescriber right away?
Does the timing of my doses matter for this combination?
Is there anything you'd monitor while I'm on both?

References (1)

Abebe W: Herbal medication: Potential for adverse interactions with analgesic drugs. J Clin Pharm Ther 2002; 27(6):391-401. PubMed

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Valerian

Keep reading about Valerian

All Valerian interactions (14)

Hydromorphone Rectal

Keep reading about Hydromorphone Rectal

All Hydromorphone Rectal interactions (344) Hydromorphone Rectal drug information

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HelloPharmacist doesn't license one of the big commercial interaction databases, so what you'll find here is not a complete list of every known drug interaction. Instead, each entry is researched, analyzed, and written up individually — documented from the published literature, reviewed by a pharmacist, and cited so you can check every source yourself.

If a combination isn't listed here, it means we haven't documented it yet — never that it's safe. For screening a full medication list, we recommend pairing this site with a comprehensive tool like the Drugs.com Interaction Checker and, most importantly, a review by your own pharmacist. For a deep, plain-English, fully sourced explanation of a specific documented interaction — that's exactly what we built this for.

This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.