Valerian

Name: Valerian Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

14 interactions 2 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

14 Moderate

All (14) Moderate (14)

Moderate

Valerian Acetaminophen And Codeine Capital® & Codeine Explained Additive central nervous system depression Details Valerian Apixaban Eliquis Explained Increased exposure of apixaban Details Valerian Dabigatran Pradaxa® Increased risk of bleeding Details Valerian Dabigatran Etexilate Increased risk of bleeding Details Valerian Diazepam Nasal Spray Valtoco Additive CNS depression or reduced effectiveness of the benzodiazepine Details Valerian Diazepam Rectal Diastat Additive CNS depression or reduced effectiveness of the benzodiazepine Details Valerian Edoxaban Savaysa Increased risk of bleeding Details Valerian Fentanyl Transdermal Patch Duragesic® Additive central nervous system depression Details Valerian Hydromorphone Injection Dilaudid Additive central nervous system depression Details Valerian Hydromorphone Rectal available generically Additive central nervous system depression Details Valerian Loperamide Diamode Delirium with symptoms of confusion, agitation, and disorientation Details Valerian Midazolam Nasal Spray Nayzilam Additive CNS depression or reduced effectiveness of the benzodiazepine Details Valerian Midazolam Injection Nayzilam Additive CNS depression or reduced effectiveness of the benzodiazepine Details Valerian Morphine Injection Astramorph® PF Additive central nervous system depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.