Hydromorphone Rectal

344 interactions 466 cited references
Also sold as: available generically
About Hydromorphone Rectal

Hydromorphone suppositories are used to relieve moderate to severe pain. Hydromorphone is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain. Read the full Hydromorphone Rectal drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isocarboxazid Naltrexone Phenelzine Safinamide Samidorphan Tranylcypromine
6 Contraindicated 329 Major 9 Moderate
All (344) Contraindicated (6) Major (329) Moderate (9)

Contraindicated

Hydromorphone Rectal Isocarboxazid Marplan An increased risk of CNS depression Details Hydromorphone Rectal Naltrexone ReVia Precipitation of opioid withdrawal symptoms; decreased opioid effectiveness Details Hydromorphone Rectal Phenelzine Nardil An increased risk of serotonin syndrome Details Hydromorphone Rectal Safinamide Xadago Increased risk of serotonin syndrome Details Hydromorphone Rectal Samidorphan Decreased opioid efficacy and precipitation of opioid withdrawal Details Hydromorphone Rectal Tranylcypromine Parnate Increased risk of serotonin syndrome or opioid toxicity and an increased risk of CNS depression Details

Major

Hydromorphone Rectal Acepromazine PROMACE Increased risk of respiratory and CNS depression Details Hydromorphone Rectal Aclidinium Tudorza Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Rectal Alfentanil Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Hydromorphone Rectal Almotriptan Increased risk of serotonin syndrome Details Hydromorphone Rectal Alprazolam Xanax Increased risk of respiratory and CNS depression Details Hydromorphone Rectal Amantadine Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Rectal Amifampridine Increased risk of seizures Details Hydromorphone Rectal Amiloride Reduced efficacy of diuretics Details Hydromorphone Rectal Amineptine Increased risk of serotonin syndrome Details Hydromorphone Rectal Amitriptyline Elavil Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Hydromorphone Rectal Amitriptylinoxide Increased risk of serotonin syndrome Details Hydromorphone Rectal Amobarbital Amytal Increased risk of respiratory and CNS depression Details Hydromorphone Rectal Amoxapine Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Hydromorphone Rectal Amphetamine Dexedrine Increased risk of serotonin syndrome Details Hydromorphone Rectal Anileridine Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Hydromorphone Rectal Aripiprazole Abilify Increased risk of respiratory and CNS depression Details Hydromorphone Rectal Aripiprazole Lauroxil Aristada Increased risk of respiratory and CNS depression Details Hydromorphone Rectal Asenapine Saphris Increased risk of respiratory and CNS depression Details Hydromorphone Rectal Atropine Atropen Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Rectal Baclofen Fleqsuvy Increased risk of profound sedation, respiratory depression, coma and death Details Hydromorphone Rectal Belladonna Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Rectal Bemetizide Reduced efficacy of diuretics Details Hydromorphone Rectal Bendroflumethiazide Reduced efficacy of diuretics Details Hydromorphone Rectal Benperidol Increased risk of respiratory and CNS depression Details Hydromorphone Rectal Bentazepam Increased risk of respiratory and CNS depression Details Hydromorphone Rectal Benzhydrocodone Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Hydromorphone Rectal Benzphetamine Increased risk of serotonin syndrome Details Hydromorphone Rectal Benzthiazide Reduced efficacy of diuretics Details Hydromorphone Rectal Benztropine Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Rectal Biperiden Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Rectal Bromazepam Increased risk of respiratory and CNS depression Details Hydromorphone Rectal Bromopride Potentiation of sedative effects Details Hydromorphone Rectal Brompheniramine Respa-BR Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Hydromorphone Rectal Bumetanide Bumex Reduced efficacy of diuretics Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.