Hydroxyurea

Name: Hydroxyurea Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

28 interactions 205 cited references

Also sold as: Droxia Droxia® Hydrea Hydrea® Siklos Siklos® Xromi

About Hydroxyurea

Hydroxyurea is an antimetabolite medication used to treat chronic myelogenous leukemia, certain head and neck cancers, and sickle cell anemia. Read the full Hydroxyurea drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Measles Virus Vaccine, Live Dengue Tetravalent Vaccine, Live Smallpox Monkeypox Vaccine Rubella Virus Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live Mumps Virus Vaccine, Live

9 Contraindicated 17 Major 2 Minor

All (28) Contraindicated (9) Major (17) Minor (2)

Minor

Hydroxyurea Probenecid Increased levels of serum uric acid Details Hydroxyurea Sulfinpyrazone Increased levels of serum uric acid Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.