Hydroxyurea and Probenecid: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Probenecid
No brand names on recordHydroxyurea
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased levels of serum uric acid
Interaction Deep Dive
Hydroxyurea may cause increased serum uric acid by temporarily interfering with renal tubular function. A dose adjustment of uricosuric agents may be warranted1. Monitor for signs and symptoms of a gout attack.
Why it happens (mechanism)
Temporary impairment of renal tubular function by hydroxyurea
Common questions
Can I take Hydroxyurea and Probenecid together?
Increased levels of serum uric acid Always confirm with your pharmacist or prescriber before making any change.
How serious is the Hydroxyurea and Probenecid interaction?
It is rated minor. Usually limited clinical impact.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Hydroxyurea or Probenecid need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: DROXIA(R) oral capsules, hydroxyurea oral capsules. Bristol-Myers Squibb Company (per FDA), Princeton, NJ, 2012. DailyMed
Keep reading about Probenecid
Keep reading about Hydroxyurea
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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